【摘要】 目的 分析比较几种常用的非甾体类消炎药(布洛芬、双氯芬酸、美洛昔康)的不良反应。 方法 将160例骨关节炎、类风湿性关节炎患者随机分成3组,分别予以布洛芬、双氯芬酸、美洛昔康治疗6个月,观察比较其消化道、心血管系统不良反应及血象变化。 结果 布洛芬组患者消化道损害发生率显著高于美洛昔康组,有统计学意义;三组患者心血管事件的发生率无统计学差异,血象变化亦无统计学差异。 结论 选择性COX-2抑制剂的消化道损害显著低于非选择性的非甾体类消炎药,但其对于心血管事件的不良影响尚不明确,临床医师用药需谨慎。

    【关键词】 非甾体类消炎药;消化道损害;心血管事件

    Research on side effects of non-steroidal anti-inflammatory drugs(nsaids)

    CHEN Xi.Department of Pharmacy, Chinese Medicine Hospital, Zhabei District, Shanghai 200072,China

    【Abstract】 Objective To analyze and compare the side effects of several commonly used NSAIDs.Methods 160 patients suffering from osteoarthritis and rheumatoid arthritis were randomly divided into three groups, and were treated with Ibuprofen, Diclofenac and Meloxicam respectively for 6 months.Then we observes their side effects on digestive and cardiovascular systems, and the changes of blood cells as well.Results The rate of digestive damage was much higher in Ibuprofen group than in Melocixam group with statistical significance.There was no significant difference as for the rate of cardiovascular accidents among these three groups.It was the same case with blood cells.Conclusions Selective COX-2 inhibitors have obviously less digestive damage than non-selective NSAIDs.However, their side effects on cardiovascular system are still not clear, so clinical physicians should be more careful when using these drugs. ......