【摘要】 目的 探讨川崎病患儿不同时期凝血功能与疾病进展的关系,为指导临床诊治、减少后天性心血管疾病提供科学依据。方法 监测KD组和对照组患儿不同时期凝血功能及与冠状动脉病变发生的关系。结果 ①KD组患儿D-二聚体升高者极显著高于对照组(P<0.01);②动态观察KD组与对照组D-二聚体升高比较<7 d组、7~14 d组差异均极显著(P<0.01),>14 d组无差异(P>0.05);③CAD组与NCAD组D-二聚体升高比较无差异(P>0.05);④动态观察CAD组与NCAD组D-二聚体升高比较<7 d组无差异(P>0.05),7~14 d组差异极显著(P<0.01),>14 d组有显著差异(P<0.05)。结论 D-二聚体可作为KD早期诊断的重要指标之一,动态观察D-二聚体具有预测冠状动脉损伤的价值。

    【关键词】动态观察;凝血功能;川崎病;早期诊断; 冠状动脉病变

    Clinical meaning of dynamic observation of blood coagulation for kawasaki disease

    XUE Xiang-ping, CAI Jun-wei, SU Su-liang

    Department of Pediatrics, Chenxinghai Hospital of Zhongshan, Guangdong 528415, China

    【Abstract】 Objective To research the relation between the progress of disease with coagulation function in different phases of kawasaki disease(KD) to provide foundation for guide the diagnosis and treatment and reduce the incidence of acquired cardiovascular disease .Methods Monitor the relation of progress of disease with coronary artery disease(CAD) in different phases of kawasaki disease(KD) and the control group ......