十味接骨药对家兔骨折骨细胞生长机理的实验研究(1)
| 第1页 |
参见附件。
【摘要】 目的 研究十味接骨药对家兔骨折骨细胞生长修复过程中骨痂中TGF-β1,羟脯氨酸、钙、磷;血清中碱性磷酸酶、钙、磷的变化和作用机理。方法 实验用健康日本大白兔81只5~6月龄造成双侧前肢0.7 cm横断性骨缺损,保留尺骨完整,并分成三组,对照组和实验组,空白组不用药,实验组给十味接骨药,对照组给骨折挫伤散。2周、5周、8周分别取材,观察十味接骨药对骨折修复的影响。结果 实验组骨痂中TGF-β1、HRP先升高后递减;血中骨痂中Ca、P峰值提前出现,血中ALP随骨生长逐渐升高。与对照组相比较统计学*P<0.01,**P<0.001。结论 十味接骨药对骨折的愈合修复有显著促进作用。
【关键词】 骨折愈合;骨细胞生长;十味接骨药
Therapeutic Effect of SHI-WEI-JIE-GU-YAO on Experimental Fracture and Its Mechanism
TIAN Qing-shan, SHUI Guo-xing,LI Kun,et al.
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154002,China
【Abstract】 Objective To study the effect of SHI-WEI-JIE-GU-YAO in the healing process of fracture. Methods Eighty-one rabbits, aged 5-6 months, had been made experimental fractures at the middle shaft of the humerus bilaterally and divided into 3 groups randomly: the blank control group, fed with common forage; the experimental group, fed with SHI-WEI-JIE-GU-YAO additionally; the drug control group, fed with GU-ZHE-CUO-SHANG-SAN ......
您现在查看是摘要介绍页，详见PDF附件。