坎地沙坦对老年慢性心力衰竭伴阵发性房颤患者P波最大时限及P波离散度的影响(1)
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【摘要】 目的 探讨坎地沙坦对慢性心力衰竭伴阵发房颤患者P波最大时限(Pmax)及P波离散度(Pd)的影响。方法 51例慢性心力衰竭伴阵发性房颤患者被随机分为坎地沙坦治疗组(治疗组26例)和对照组(25例),慢性心力衰竭基本治疗两组相同,治疗组加用坎地沙坦2～4 mg/d,在治疗前、治疗后6个月分别测量Pmax和Pmin,计算出Pd(Pd=Pmax-Pmin)。结果 治疗前两组Pmax和Pd比较无显著差异(P>0.05);治疗6个月治疗组的Pmax、Pd显著降低,与对照组相比有显著意义(P<0.01);而对照组治疗前后相比没有差异(P> 0.05)。治疗组房颤发作次数明显减少,与对照组比较差异有显著意义(P<0.01),结论 坎地沙坦治疗慢性心力衰竭伴阵发性房颤患者可明显降低Pmax、Pd,减少房颤发作次数。
【关键词】 心力衰竭; 心房颤动; P波离散度;坎地沙坦
The effect of Candesartanon Pmax and Pd in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation
HUANG Wei-jun.
Department ofinernal medcine, Huangjiang hospital, Dongguang, Guangdong,523750
【Abstract】 Objective To investigate the effects of candesartan on Pmax and P wave dispersion(Pd)in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation(PAF).Methods 51 chronic cardiac insufficiency patients were randomly divided into candesartan treatment group(treatment group。n= 26)and control group(n= 25). Basic treatment of chronic cardiac insufficiency in two groups was comparable.The patients in treatment group were treated by candesartan 2～ 4 mg/d.Pmax and Pd were measured based on the 1 2-lead electrocardiogram at the beginning and at the six months after taking medicine.Results At the beginning there was no significant difference between two groups(P>0.05);Pmax and Pd were significantly decreased in treatment group after 6 months compared to that of control group (P<0.01); but it was not significant in control group (P>0.05).PAF rate was decreased after 6 months treatment and compared to that of control group (P<0.01). The difference was significant in control groups(P
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