幽门螺杆菌阴性消化性溃疡并发出血的危险因素分析(1)
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【摘要】 目的 探讨幽门螺杆菌阴性消化性溃疡并发出血的危险因素。方法 对138例幽门螺杆菌阴性消化性溃疡的影响因素采用病例-对照研究的方法。117例发生并发症出血。研究项目包括:性别、年龄、吸烟史、饮酒史、腹痛、休克表现、高血压、冠心病、糖尿病、服用非甾体抗炎药情况、心理因素、伴随疾病、溃疡情况、血脂异常、凝血功能异常、血小板计数、血红蛋白值。 结果 单因素分析显示无腹痛(P=0.003)、有休克表现(P=0.004)、伴随疾病者(P=0.005)、溃疡活动期(P=0.003)有统计学意义;进行Logistic回归模型多因素分析显示:无腹痛、有休克表现、伴随疾病者、溃疡活动期有统计学意义(P<0.05)。结论 无腹痛、有休克表现、伴随疾病者、溃疡活动期与幽门螺杆菌阴性Pu并发出血相关。其中,无腹痛、有休克表现、伴随疾病者、溃疡活动期为幽门螺杆菌阴性Pu并发出血的独立危险因素。
【关键词】 消化性溃疡;幽门螺杆菌;出血;危险因素
Analysis of Risk Factors of Hemorrhage in Helicobacter pylori-negative Peptic Ulcer
WENG Zhi-xiong,YU Zhi-jin,LIU Zhi-hong,et al.The Medical Emergency and wound Center,The central people’s hospital of Huizhou,Huizhou 516001,China
【Abstract】 Objective To investigate the risk factors of Hemorrhage in Helicobacter pylori-negative Peptic Ulcer.Methods Among the 138 Helicobacter pylori-negative Peptic Ulcer cases,Bleeding were occurred in 117 cases.The relations among the sex,age,smoking,ingestion of alcohol,abdominal pain,shock behavior,hypertension,coronary heart disease,diabetes mellitus,the use of non-steroidal anti-inflammatory drugs,mood disorder,concomitant diseases,the ulcer condition,dyslipidosis,thromboasthenia,platelet count,hemoglobin count were analyzed.Results Univariate analysis identified 4 statistically significant variables,including without abdominal pain(P=0.003),shock behavior(P=0.004),concomitant diseases(P=0.005),active stage ulcer(P=0.003).Logistic stepwise regression analysis showed that without abdominal pain,shock behavior,concomitant diseases,active stage ulcer were correlated with bleeding in H.pylori-negative PU(P<0.05).Conclusion Without abdominal pain,shock behavior,concomitant diseases,active stage ulcer are correlated with bleeding in H.pylori-negative PU.Whereas without abdominal pain,shock behavior,concomitant diseases,active stage ulcer are independent risk factors of bleeding in H.pylori-negative PU.
【Key words】Peptic ulcer; Helicobacter pylori; Hemorrhage; Risk Factors
基金项目:广东省惠州市科技局科研课题项目(项目编号:20090602)
作者单位:516001广东省惠州市中心人民医院急救与创伤中心(翁志雄 刘志红), 腔镜中心(余志金), 消化内科(陈惠新 严山), 病理科(彭晓峰)
消化性溃疡(Peptic ulcer,Pu)最常见的并发症是出血。大量研究已证明幽门螺杆菌(H.pylori,HP)感染是引起Pu的重要病因,但随着国内外日益重视根除HP感染,HP相关性溃疡的发病率逐步下降,而HP阴性消化性溃疡的发病率日趋增加[1] ......
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