同型半胱氨酸与糖尿病及其血管并发症的Meta分析(1)
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【摘要】 目的 利用对大样本数据Meta分析的方法,对糖尿病及其合并并发症的糖尿病患者进行血浆同型半胱氨酸浓度的分析,探讨血浆同型半胱氨酸(homocysteine,Hcy)的水平与糖尿病血管并发症的关系。方法 计算机检索中国期刊网全文数据库、中国生物医学文献数据库、万方数据库和维普数据库,并结合文献追溯的方法,收集2003~2010年关于血浆Hcy水平与糖尿病及其并发症的病例研究资料,以健康人群为对照组,糖尿病伴有血管并发症患者为病例组,采用采用RevMan4.2软件进行Meta分析。结果 共纳入16个研究,包括1420例研究对象。Meta分析结果显示糖尿病合并血管并发症组Hcy水平明显高于正常对照组,其差异有统计学意义[WMD=9.12,95%CI(8.85,9.39),P<0.00001]。结论 血浆Hcy的水平与糖尿病及其血管并发症之间的关系密切。
【关键词】血浆同型半胱氨酸;糖尿病血管并发症;Meta分析
A meta analysis of homocysteine level in patients with diabetes mellitus and its vascular complications
【Abstract】 Objective Using the meta analysis method to analyze homocysteine level in patients with diabetes mellitus and its vascular complications to investigate the relationship between homocysteine level and diabetes mellitus and its vascular complications. Methods A computer based search of Chinese journal full text database,CBMdisc,WANFANG DATA and VIP INFORMATION was performed. Domestic researches about the case study data of homocysteine level in patients with diabetes mellitus and its vascular complications published between 2003 to 2009 were collected. Healthy people as control group, patients with diabetes mellitus and vascular complications as case group. Using the RevMan4.2 software to meta analyze. Results There are 16 total studies. Of which 1420 cases as study object. The meta analysis showed that the homocysteine level to case group were significantly higher than the control group.The differences was statistically significant[WMD=9.12,95%CI(8.85,9.39),P<0.00001]. Conclusion The paper showed a close relationship between homocysteine level and diabetes mellitus and its vascular complications.
【Key words】 Homocystein;Diabetes mellitus and its vascular complications;
Meta analysis
作者单位:510120中山大学孙逸仙纪念医院药学部
糖尿病(diabetes,DM)是以高血糖为特征的全面代谢紊乱性疾病。而DM的血管并发症是致残和致死的主要原因。糖尿病血管病变(diabeticvasculo pathy,DVP)分为微血管病变(diabetic microangiopathy,DMIP)和大血管病变(diabetic macroangiopathy,DMAP)。DMAP的基本病理改变为动脉粥样硬化(AS),增加了心肌梗死、中风、间歇性跛行和缺血性坏疽的危险性[1]。
高血糖是由于胰岛素分泌缺陷和(或)胰岛素作用缺陷而引起。除碳水化合物,尚有蛋白质、脂肪代谢异常。目前,大部分文献认为高 Hcy血症是心、脑及外周血管病变的独立危险因素[2] ......
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