天津市近26年黑色素瘤发病分析
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【摘要】 目的 探讨天津市近26年黑色素瘤发病趋势及特点,为临床和病理医生提供有价值的诊断思路。方法 材料来自天津医科大学总医院及天津医科大学二院病理科1981 2006年外科病理检查黑色素瘤资料,以MICROSOFTEXCEL 表格形式存储,列统计表显示黑色素瘤26年检出趋势,分别计算年龄及部位构成比及平均确诊年龄,对不同性别的黑色素瘤进行t检验。结果 26年来黑色素瘤皮肤最好发,其次口腔、直肠、阴道。检出男57例,女68例。女性略多于男性,男女之比为0.83:1。年龄范围从25~77岁,平均年龄54岁。 结论 黑色素瘤发病年龄趋于年轻化,内脏发病有增高趋势,皮肤发病趋于消减,这与人们防治意识提高及对皮肤病变早期手术有关。
【关键词】 黑色素瘤;发病趋势; 病理检查
Incidence of M alignant Melanoma during the past 26 years in Tianjin
WU xing ye,WANG xin yun.
Tianjin Medical UniversityDepartment of Pathology,Tonghua center’s hospital,Jilin 134000 Pathological staffH foom of Tianjin University Tianjin 300070,China
【Abstract】 Objective To study the incidence and its tendency of m alignant melanoma during the past 26 years and to provide information for clinicians and pathologists.Methods The data of m alignant melanoma were collected from the General Hospital and the Second Hospital of Tianjin Medical University.The data from 1981 to 2006 were stored in Excel.The tendency of m alignant melanoma during the last 26 years was showed by statistic graph.The proportion,sex and average ages of every type of m alignant melanoma were calculated and analyzed by T test or ANOVA.Results The common site of m alignant melanoma during 26 years was skin,second to it was oral cavity,rectum,vagina.The cases of male were 57 and female were 68.The incident of m alignant
melanoma is higher in female than it in male.The relative ratio of male to female was 0.83:1.The ages were arange from 25 to 77 years old and the average age was 54 years. Conclusion The onset of m alignant melanoma is more and more in the youngers.Its incident is highter in internal organs and lower in skin.It is associated with people’s more attention to m alignant melanoma and early operation on pathological changes on skin.
【Key words】 Melanotic carcinomas;Tendency; Pathological examination
近26年来,肿瘤发病率不断上升,恶性肿瘤更威胁人类健康,由于地理位置、经济发展和生活水平不一致,肿瘤好发部位差异很大,为探讨天津市近26年黑色素瘤的发病趋势和特点,作者统计了天津医科大学总医院及第二医院病理科近26年黑色素瘤的检查资料进行分析,希望能提供有价值的诊断思路。
1 材料和方法
1.1 材料 来自天津医科大学总医院及第二医院病理科1981/2006年外科病理检查黑色素瘤标本,两所医院为三级甲等医院,有代表性。全部标本经甲醛固定,石蜡包埋,切片,HE染色,根据WHO肿瘤国际组织学分类[1],重新进行审核。以Microsoft Excel 表格形式存储,计算黑色素瘤构成比及确诊年龄,对黑色素瘤患者年龄进行t检验。
2 结果
2.1 黑色素瘤发病特点:26年间检出肿瘤125例,男性57例,女性68例,男女之比为0.83:1。
2.2 黑色素瘤性别和年龄:26年来男、女分前13年确诊年龄及后13年的确诊年龄两组进行t检验,经统计学检验有意义(P<0.0005),年龄范围从25~77岁,平均年龄54岁。见表1。
表1
天津市表黑色素瘤的男女两性平均确诊年龄(x±s,岁)
年份男性女性
例数年龄(x±s)例数 年龄(x±s)
t值P值
1981/1993 2748.2±11.13052.4±13.1 8.808 <0.0005 ......
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