孟鲁司特联合布地奈德治疗支气管哮喘的临床研究(1)
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【摘要】 目的 观察孟鲁司特联合布地奈德吸入治疗儿童支气管哮喘的临床疗效。方法 选取中、重度支气管哮喘急性发作患儿30例,随机分对照组和治疗组,每组各15例。对照组采用激素、多索茶碱常规治疗,治疗组采用布地奈德每日两次雾化吸入、孟鲁司特4 mg,1次/d睡前口服治疗。疗程均为10 d。记录患者临床症状缓解时间;两组治疗前和治疗后10 d各进行一次肺功能测定和嗜酸性粒细胞计数,数据进行统计学分析。结果 两组患儿经过治疗后肺功能FEV1/FVC%、PEF均明显上升(P<005),治疗组较对照组上升更明显(P<005)。并且治疗组患儿临床症咳嗽、喘息的缓解时间明显短于对照组(P<005)。经过治疗后两组患儿EOS计数均下降明显(P<005),治疗组与对照组相比下降更为明显(P<005)。结论 孟鲁司特联合布地奈德吸入治疗可以有效地改善中、重度哮喘患者的肺功能,缓解哮喘症状,降低EOS计数,从而有效的控制哮喘的发作。
【关键词】
支气管哮喘;孟鲁司特;布地奈德
The Clinical Observation of Montelukast association with Budesonideon Patients with Bronchial Asthma
LIU Helin,GAN Bin.
Department of Pediatrics,Xiaogan Hospital,Xiaogan 432100,China
【Abstract】 Objective To observe the joint montelukast and budesonide treatment of child bronchial asthma in clinical efficacy Metheods Thirty child bronchial asthma patients in medium and severe acute episode were randomly divided into the control group and treatment group and there were fifteen patients in every groupThe patients in the control group were applied antibiotic、hormone and doxofylline and the patients in the treatment group were applied antibiotic、budesonide atomizationed two times everyday and four mildigram montelukast took orally one time ahead sleepy everydayThe time of therapy was ten daysThen we recorded the time that clinical symptom reliefed and carried out lung function tests and the amount of the eosinophile granulocyteLater we taked the statistics analysisResults The lung function as FEV1/FVC%、PEF of the patients in two groups rised obviously (P<005)and more obviously in the treatment group(P<005)The time that clinical symptom as cough and pursiness reliefed for the treatment group was less than the the time for the control group(P<005)The amount of the EOS to the two groups decend obviously after treatment(P<005)and more obviously in the treatment group(P<005)Conclusion Montelukast association with budesonideon could efficiently improve the lung function of the medium and severe bronchial asthma patients and relief the symptoms of asthma,also decended the amount of the EOS,thus efficiently control the asthmatic attack ......
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