综合疗法治疗急性一氧化碳中毒的疗效观察(1)
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【摘要】 目的 观察纳洛酮联合高压氧综合疗法治疗急性一氧化碳中毒的临床疗效。方法 我科于2008年11月至2010年2月共收治97例急性一氧化碳中毒患者,随机分为对照组48例和观察组49例。两组患者均给予常规的对症支持治疗,对照组给予高压氧治疗,观察组在对照组的基础上给予纳洛酮,观察两组的临床疗效。结果 观察组的总有效率为959%,对照组的总有效率为688%,两组比较差异有统计学意义(P<005);观察组的平均昏迷时间和迟发性脑病及病死率与对照组比较差异亦有统计学意义(P<005)。结论 纳洛酮联合高压氧综合疗法治疗急性一氧化碳中毒疗效显著,能明显缩短患者昏迷时间,减少迟发性脑病的发生率及病死率,值得推广应用,
【关键词】
一氧化碳中毒;综合疗法;纳洛酮;高压氧
To observe the efficacy of combined therapy in treatment of acute carbon monoxide poisoning
ZHANG Jianxin.
Department of Emergency,First Affiliated Hospital of Xinxiang Medical College Henan 453100,China
【Abstract】 Objective To observe the clinical efficacy of naloxone combined with hyperbaric oxygen in treatment of acute carbon monoxide poisoning Methods 97 patients with acute carbon monoxide poisoning in our department from November 2008 to February 2010 were divided into the control group(48 cases) and the observation group(49 cases) Both of the two groups were treated by conventional symptomatic and supportive therapy, the control group was given highpressure oxygen therapy,and the observation group were added naloxone at the basis of the control group The clinical efficacy was observed Results The total effective rate of the observation group was 959% and the control group was 688%, the difference was statistically significant (P<005).The difference of the average coma time, the rate of delayed encephalopathy and mortality in the observation group were also statistically significant (P<005) compared with the control groupConclusion Naloxone combined with hyperbaric oxygen in treatment of acute carbon monoxide poisoning has a significant effect, and it can significantly shorten the coma time patients, reduce the rate of delayed encephalopathy and mortality It is worth to promote
【Key words】
carbon monoxide poisoning;Combined therapy; Naloxone; Hyperbaric oxygen
急性一氧化碳中毒(ACOP)多发生在冬季,并多见于我国北方地区。一氧化碳中毒会对脑组织产生损伤,并且严重者会产生迟发型脑病,据报道其临床发生率可高达10%~30%以上。特别是对于老年患者,发病多以中重度为主,很容易并发多脏器功能衰竭,并且迟发性脑病的发生率、死亡率和致残率均很高[1]。临床上多应用高压氧配合治疗,但效果不明显。纳洛酮属于阿片受体拮抗剂,在临床上被用于休克、脑梗死及酒精中毒等,疗效确切。为了提高急性一氧化碳中毒的临床疗效,减少后遗症,我们应用纳洛酮联合高压氧综合疗法对急性一氧化碳中毒患者进行了治疗,现将结果报告如下。
1 资料和方法
11 一般资料
我科于2008年11月至2010年2月收治的97例患者,参照第6版《内科学》[2]中急性一氧化碳中毒的诊断标准,均明确诊断为急性一氧化碳中毒 ......
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