P-选择素及高敏C反应蛋白在高血压发生冠心病事件中的作用(2)
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本研究观察时间短,样本还不够大,今后将在此基础上扩大样本量,对单纯高血压患者进行长期的随访研究并观察其心血管不良事件的发生率,并评估与血小板活化及炎症的关系。这将有利于深入了解P-选择素在高血压发生CAD事件中的作用,为高血压患者早期采用有效的抗血小板活化药物治疗提供可靠依据。
参 考 文 献
[1] Andreas E. May, Peter Seizer, Meinrad Gawaz. Aplatelets: inflammatory firebugs of vascular walls. Arteriosclerosis, Thrombosis, and Vascular Biology, 2008,28:5-10.
[2] Steinhubl SR, Moliterno DJ. The role of the platelet in the pathogenesis of atherothrombosis. Am J Cardiovasc Drugs,2005,5(6):399-408.
[3] 金露.复方丹参滴丸对冠心病不稳定性心绞痛患者血小板活化功能的影响.中国中西医结合杂志, 2000,20(6):415-417.
[4] 金露.不稳定性心绞痛患者内皮及血小板活化功能检测的临床意义.中国循环杂志, 2000; 15(1):18.
[5] 金露,罗海明,符德玉,等.红景天对高血压患者P选择素的影响.实用医学杂志,2005,21(9):988-990.
[6] Blake GJ, Rifai N, Buring JE, et al.Blood pressure, C-Reactive protein, and risk of future cardiovascular events. Circulation,2003,108: 2993 -2999.
[7] Burger PC, Wagner DD. Platelet P-selectin facilitates atherosclerotic lesion development. Blood, 2003,101:2661–2666.
[8] Koyama H, Maeno T, Fukumoto S,et al. Platelet P-Selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Circulation,2003,108:524-529.
[9] Ridker PM, Buring JE, Rifai N.Soluble P-Selectin and the risk of future cardiovascular events. Circulation,2001,103:491-495.
[10] Nomura S, Shouzu A, Omoto S,et al. Losartan and simvastatin inhibit platelet activation in hypertensive patients. J Thromb Thrombolysis,2004,18(3):177-185.
[11] Song CJ, Nakagomi A, Chandar S,et al.C-reactive protein contributes to the hypercoagulable state in coronary artery disease. J Thromb Haemost,2006,4(1):98-106.
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