治疗60例胃相关性口腔扁平苔藓的临床经验探讨(1)
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【摘要】 目的探讨有效治疗胃相关性扁平苔藓的方法。方法 随机将60例口腔扁平苔藓并伴有胃病患者分为治疗组与对照组。对照组采用2%利多卡因加曲安奈德作黏膜下封闭，治疗组在封闭治疗的基础上，消除口腔及牙齿局部不利因素，并且给予补充维生素、钙制剂，给予复方铝酸铋胶囊(威安)治疗胃病，配合氯喹、白芍总苷及心理干预治疗，观察各组的有效率及复发率，观察外周血治疗前、后T淋巴细胞亚群的变化。结果 治疗组总有效率为93.33%，对照组为90.00%，经统计学处理，差异无统计学意义(P>0.05)。随访1年治疗组复发率21.43%，对照组77.78%，统计学差异有统计学意义(P<0. 01)。治疗后CD3、CD4、CD4/CD8升高，CD8降低。IgA、IgG含量变化差异有统计学意义(P<0.05)。结论 采用系统治疗胃相关性口腔扁平苔藓是一种有效的治疗方法。
【关键词】 治疗;胃相关性;口腔扁平苔藓
Treating 60 cases ofstomach-relatedclinical experience of oral lichen planus
DONG Yan-Li.Department of stomatology,Zaozhuang Metrolips Hospital. ShanDong, Zaozhuang277100,China
【Abstract】 ObjectiveTo investigatethemethodof curingthe OLPof the stomachrelativity. Methods 60 OLP patients of the stomachrelativity were randomly divided into treatmentgroup(n=30)andcontrol group(n=30).The control groupwas treated to use 2% lidocainum plus TriamcinoloneAcetonidefor submucosal closed. In a closed foundation,the treatment group was treatedto eliminate oral and dental partialnegative factors, and given vitamin supplements, calcium preparations, to give Compound Bismuth Aluminate Capsules(Weian)in treatment of stomach, with HydroxychloroquineSulfateTablets, TotalGlucosidesofWhitePaeonyCapsules and psychological intervention.To observe the rate of efficient andrecurrence. To observe the changes in peripheral blood before and after treatment in T lymphocyte subsets and immunoglobulin.Results The treatment group isefficientfor93.33%, the control group for90.00%.Statistically,therewas no significant difference(P>0.05).Follow-up 1 year the treatment group recurrence rate was 21.43%, the control group 77.78%, statistically,therewas significant difference(P<0. 01). After treatment CD3, CD4, CD4/CD8 increased, CD8reduced. IgA, IgG concentration changes are significant(P<0.05).Conclusion Used for the system treatment of stomach-related oral lichen planus is an effective treatment.
【Key words】 Therapy; Stomach related; Oral lichen planus(OLP)
口腔扁平苔藓的发病原因及发病机制至今尚不清楚，国内外的研究表明，OLP与慢性胃炎关系密切，临床发现，胃炎患者经过治疗，OLP的症状和体征相应减轻。我科从2004年1月至2006年12月对30例胃相关性扁平苔藓患者采取系统治疗，取得了较好的疗效，现报告如下。
1 资料和方法
1.1 一般资料 所选病例为2004年1月至2006年12月与枣庄市立医院口腔科就诊的60例OLP患者，且胃病发现在OLP之前(根据患者口述 ......
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