60例颈动脉狭窄患者 hs-CRP\Hcy含量变化的研究(1)
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【摘要】 目的 研究60例颈动脉狭窄患者 hs-CRP、Hcy含量变化。方法 将2009年9月至2010年12月收入我院的60例颈动脉狭窄患者设为实验组，对照组62例均来自门诊健康体检者。采用荧光偏振免疫法和放射免疫比浊法分别测定Hcy、hs-CRP的浓度，采用颈动脉彩超、MRA或CTA检查颈动脉内膜厚度、有无斑块及狭窄。两组患者的年龄、性别等经统计学分析，差异无统计学意义(P>0.05)，具有可比性。结果 经测定实验组血浆Hcy的平均浓度为(20.4±7.6)μmol/L，对照组血浆Hcy的平均浓度为(10.4±1.2)μmol/L，经统计学分析，(P<0.01)，差异具有统计学意义，即实验组血浆Hcy的水平高于对照组；实验组血清hs-CRP为(8.03±1.93)mg/L,对照组血清hs-CRP为(1.06±0.9)mg/L，经统计学分析，(P<0.01)，差异具有显著性，即实验组血清hs-CRP的水平高于对照组。结论 hs-CRP、Hcy含量与颈动脉狭窄程度呈显著正相关，hs-CRP、Hcy可能成为脑血管疾病治疗的新靶点。
【关键词】 颈动脉狭窄；支架置入术；hs-CRP；Hcy
Hs-CRP, Hcy Content Change Research in 60 patients of Carotid Artery Stenosis
LIU Ke-jing, ZHANG Zhong-guang, XUE Chun-yu.Qingdao University Medical College,266021 China
【Abstract】 Objective To study the change of hs-CRP,Hcy content of 60 cases of carotid artery stenosis, Hcy content. Methods experimental group were 60 cases of carotid artery stenosisfrom September 2009 to December 2010 were incomed, control group were 62 healthy persons from the clinic. fluorescence polarization immunoassay and radioimmunoassay were used to determine Hcy, hs-CRP levels, used Carotid ultrasound, MRA or CTA to examin carotid artery intima-media thickness, with or without plaques and stenosis. Both groups no age, sex and the statistical analysis had no significant difference (P>0.05).Results The experimental determination of the mean plasma Hcy concentration was (20.4±7.6)μmol/L, control group, the mean plasma Hcy concentration was (10.4±1.2) μmol/L, by statistical analysis, P<0.01, significant difference, that experiment had higher plasma Hcy levels; experimental serum hs-CRP was (8.03±1.93) mg/L, serum hs-CRP in control group was (1.06±0.9) mg/L, by statistical analysis, (P<0.01),there was significant difference, that is experimental serum hs-CRP levels higher. Conclusion hs-CRP, Hcy content and degree of stenosis are significantly correlated,they will be the new target to care the cranial vasculare diease.
颈动脉狭窄主要是由于颈动脉的粥样斑块导致，发病部位多位于颈内动脉起始段和颈总动脉分叉，多见于60岁以上，发病率较高，影响患者的生命和生存质量。颈动脉狭窄是导致缺血性脑卒中的重要原因之一, 具有高致残率和死亡率，颈动脉内膜剥脱术(CEA)和血管内支架治疗是治疗颈动脉狭窄的有效方法[1, 2]。近年来, hs-CRP、Hcy与颈动脉狭窄及其程度的关系开始受到人们的重视,但其机制目前尚不清楚。本研究旨在探讨我院2009年9月至2010年12月收入院的60例颈动脉狭窄患者 hs-CRP、Hcy含量变化。现报告如下。
1 资料与方法 ......
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