保妇康栓治疗宫颈炎合并HPV感染的临床研究(1)
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【摘要】 目的 探讨保妇康栓治疗宫颈炎合并人乳头瘤病毒(HPV)感染的确切疗效。方法 选取2008年1月至2010年1月在开封市中医院妇科门诊确诊的宫颈炎合并HPV感染≥2年患者作为观察病例，按照随机、对照的原则分为治疗组和对照组，其中治疗组76例，保妇康栓阴道用药，对照组60例，干扰素栓阴道用药，两组均2周为1疗程，均用药3个疗程，疗程结束后2周内复诊，对两组治疗前后妇科检查及杂交捕获二代(HC Ⅱ)、液基细胞学(TCT)检测结果进行统计学分析。结果 两组HPV(RLU/CO值)疗效比较P=0.434>0.05，两组疗效相当；两组宫颈炎(TCT积分+宫颈糜烂积分)疗效比较P=0.045<0.05，治疗组疗效优于对照组。结论 保妇康栓疗效确切，具有抗HPV感染、抗菌、消炎的作用，值得在临床推广应用。
【关键词】 宫颈炎；人乳头瘤病毒；中药；保妇康栓
【Abstract】 Objective To study the exact clinical efficiency of Baofukang uppository in treating cervicitis combined with human papillomavirus (HPV) infection.Methods The patients sufferd from cervicitis with HPV infection persisted ≥2years,between January 2008 to January 2011 at TCM Hospital of Kaifeng City,were randomly divided into treatment group and control group,the treatment group included 76 patients were given Baofukang uppository,the control group included 60 patients were given Ganraosu uppository.Both group were treated for 2 weeks as a course,and every group was treated for 3 courses,2 weeks later after 3 courses,all the patients came back accepted gynecological examination,TCT and HC Ⅱ test,and the changes of gynecological examination,TCTand HC Ⅱ test before and after treaiment were observed and analyed respectively.Results The effect of HPV between treatment group had no significant difference(P=0.434>0.05).As asignificant difference was demonstrated between the two groups in cervicitis index(TCT index and cervical erosion index)(P=0.434>0.05),There was much better effect in test gongp than control group.Conclusion Baofukang uppository has anti-HPV infection,anti-Bacterial,anti-inflammatory efficacy,which exact clinical efficiency was suitable for clinical application.
【Key words】 cervicitis;human papillomavirus;chinese medicine;Baofukang uppository
宫颈炎是已婚妇女的常见病、多发病，合并人乳头瘤病毒(human papillomavirus,简称HPV)感染成为宫颈癌发生的必要病因之一[1]，30岁以上持续性(≥2年)HPV感染的妇女是宫颈癌的高危人群[2]。目前，对HPV感染的治疗，主要是西药干扰素栓剂的局部使用，具有一定的临床疗效。
中成药保妇康栓主要含冰片及莪术油等抗肿瘤细胞和抗病毒的成分，目前临床广泛用于宫颈炎、阴道炎的治疗[3]。我们进行此项研究的目的是验证保妇康栓阴道局部用药的抗HPV确切疗效，为临床应用保妇康栓治疗宫颈HPV感染提供有力的证据。
1 资料与方法
选择2008年1月至2010年11月在开封市中医院妇科门诊确诊为宫颈炎合并HPV感染患者作为观察病例，按照随机、对照原则分为治疗组和对照组。其中治疗组76例，保妇康栓阴道用药，对照组60例，干扰素栓阴道用药，两组均2周为1疗程 ......
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