辛伐他汀对心肌梗死后无症状心衰患者NT proBNP及心功能的影响(1)
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【摘要】 目的 观察辛伐他汀对心肌梗死后无症状心衰(silent heart failure, SHF)患者氨基末端脑钠肽前体(NT proBNP)、心室重构的影响。方法 90例陈旧性前壁心肌梗死患者(NYHAⅠ级)在常规治疗基础上加服辛伐他汀，43例服辛伐他汀12个月设为观察组，47例1个月内停服辛伐他汀设为对照组，比较两组治疗前一般资料、治疗前和治疗12个月后血浆NT proBNP左室重构及功能相关指标的变化 结果 两组治疗后血浆NT proBNP水平均较治疗前显著降低(P<0.05)，治疗后观察组血浆NT proBNP水平显著低于对照组(P<0.05)。治疗后，两组左室质量指数(LVMI)、左室舒张末期内径(LVEDD)、舒张末左室后壁厚度(LVPWT)较治疗前均显著降(P<0.01)，观察组LVMI、LVPWT显著小于对照组(P<0.01)；两组舒张末室间隔厚度(IVST)、左室短轴缩短率(FS)较治疗前均显著增加(P<0.01)，观察组 IVST、FS显著大于对照组(P<0.01)。结论 常规治疗基础上加用辛伐他汀能进一步改善心肌梗死后无症状心衰患者心功能并减轻心室重构，延缓临床心衰的发生。
【关键词】辛伐他汀；无症状心衰；氮末端脑钠肽前体；心肌梗死
Effects of simvastatin treatment on plasma NT ProBNP and Left ventricular function in patients with silent heart failure
QIU Bing hua， SONG Hai bin， ZHANG Yan zhen， et al.
Weifang Medical college in Kuiwen Distritt,Weifang 261041,China
【Abstract】 Objective To observe the effects of simvastatin on plasma NT ProBNP and left ventricular remodeling in patients of silent heart failure.
Methods 43 patients that finished 12 months treatment with simvastatin were divided into observer group(treated by 40 mg Simvastatin+conventional treatmeant)and 47 patients that treated by conventional treatment were divided into control group.The changes of plasma NT ProBNP levels and parameters of left ventficular remodeling before treatment and 12 months after treatment were compared between two group Results the plasma levels of NT proBNP after treatment in observer group were significantly lower than those in control group(P<0.05), LVMI and LVPWT in observer group were significantly lower than those in control group(P<0.01). IVSTand FS in observer group were significantly higher than those in control group(P<0.01). Conclusion Simvastatin has beneficial effects on cardiac function and left ventricular remondeling of silent heart failure patients.
【Key words】Simvastatin; Silent heart failure;Myocardial infarction;NT proBNP
无症状心力衰竭是指临床确有心力衰竭的客观证据, 但缺乏气喘、胸痛、呼吸困难及与心肌缺血相关的主观症状[1]，往往不引起医患的重视, 潜在危险性较大。早期诊断并治疗对阻断或延缓心衰进展，改善无症状性心衰患者的预后非常重要。本研究观察了应用辛伐他汀对心肌梗死后无症状心功能不全患者血浆NT proBNP浓度及心功能的影响 ......
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