康莱特注射液在食管鳞癌患者化疗过程中的作用(1)
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【摘要】 目的 探讨康莱特注射液对食管鳞癌患者副反应、免疫功能和化疗疗效的影响。方法 98例食管鳞癌患者分为实验组和对照组，每组49例，对照组采用“5-氟尿嘧啶+顺铂”或“紫杉醇+顺铂”方案化疗，实验组在化疗的基础上加用康莱特注射液。结果 对照组和实验组化疗有效率差异无统计学意义(P>0.05)，实验组严重消化道反应、严重骨髓抑制和乏力的发生率显著低于对照组(P<0.05)。对照组和实验组化疗前后CD3+和CD8+差异无统计学意义(P>0.05)。对照组化疗后CD4+T细胞百分数减少，CD4+T细胞/CD3+T细胞比值降低(P<0.05)；实验组化疗后CD4+T细胞百分数增高，CD4+T细胞/CD3+T细胞比值增高(P<0.05)。结论 康莱特注射液可以减轻食管鳞癌化疗的副反应，提高患者的免疫能力。
【关键词】 康莱特；食管鳞癌；化疗
The effect of kanglaite in the chemotherapy to patients with esophageal squamous cell cancer
SONG Chao-gong. The first Rongkang Hospital of Xinxiang City,Henan 453000,China
【Abstract】 Objective To investigate the influence of Kanglaite injection to the curative effect, adverse reaction and immune function of patients with esophageal squamous cell cancer. Methods 98 patients with esophageal squamous cell cancer were randomly divided into two groups: experimental group and control group.49 patients in control group acceptd chemotherapy with “5-fluorouracy and cisplatin” or “paclitaxel and cisplatin”.70 patients in experimental group acceptd the treatment with Kanglaite injection and chemotherapy. Results No apparently curative difference between two groups. Incidence of serious digestive reaction and serious myeloid inhibition in experimental group was apparently lower than that in control group. After chemotherapy, the percentage of CD3+T cell and CD8+T cell did not apparently modify. In control group, after chemotherapy, the percentage of CD4+T cell and CD4+ T /CD3+T ratio was decreased. However, in experimental group, the percentage of CD4+T cell and CD4+ T /CD3+T ratio was elevated after chemotherapy. Conclusion Kanglarte injection can alleviate the adverse reaction which caused by chemotherapy and enhance the organism immune.
【Key words】 Kanglaite injection；Esophageal squamous cell cancer；Chemotherapy
食管癌患者由于饮食状况不佳常导致体质虚弱，机体免疫功能降低。在接受化疗的过程中消化道反应导致饮食状况下降，机体免疫功能受到进一步抑制，不利于患者继续治疗和康复。而中医药扶正治疗在食管癌的综合治疗中发挥着重要的作用，也是我国在食管癌治疗领域的特色。我国食管癌患者中绝大部分为鳞癌。康莱特注射液主要成分为中药薏苡仁提取物，具有提高机体免疫能力的作用。作者探讨食管鳞癌患者化疗过程中联合应用康莱特注射液对化疗疗效、副反应和机体免疫能力的影响。
1 资料与方法
1.1 一般资料 98例食管癌患者为河南第一荣康医院内科和郑州大学第一附属医院肿瘤科2008年6月至2010年2月收治的患者，其中男66例、女32例。中位年龄61岁。所有患者均经组织病理学证实为食管鳞癌 ......
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