高血压病对肱-踝脉搏波传导速度影响的研究(2)
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高血压病可加速动脉粥样硬化病理性过程。长期血压增高时可引发全身小动脉病变，从而促进动脉粥样硬化形成与发展。动脉粥样硬化最显著临床表现是PP增加[9]。baPWV是准确反映动脉粥样硬化程度的早期指标。同时SBP、DBP与MAP与baPWV存在正相关[10]。baPWV大小可反映动脉壁僵硬程度。一般动脉管壁顺应性越大，baPWV就越慢[11]。本研究中N组与P组、O组、T组比较，SBP与DBP皆逐渐增高，同时PP与MAP也逐渐升高。四组中SBP、DBP、PP与MAP两两相比较皆有显著差异(all P<0.05)，同时baPWV也逐渐增高，且四组的baPWV检测值两两比较存在明显差异(all P<0.05)，说明baPWV与血压存在明显相关性。说明动脉粥样硬化不仅是血压增高的一种血管适应性反应，而且是血压增高的一种基础性病理生理性原因[12，13]。
2003年欧洲高血压指南提出治疗高血压病时将PWV作为心血管事件的预测指标及评价降压药物疗效方法之一[14]。2007年欧洲高血压病指南建议将PWV检测作为高血压病患者靶器官损害的亚临床指标[15]。如果单纯降低血压而PWV没有得到明显改善，降压药物未必能降低心血管病的发病率及死亡率[16]。本研究通过证实高血压病患者不同血压水平与baPWV的显著相关性，说明PWV在高血压诊断与治疗及预防中的重要作用。可为未来高血压病的深入研究提供一种新的思路。
参考文献
[1] Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pre-ssure. Hypertension,2003,42(6):1206-1252.
[2] Boutouyrie P, Laurent S, Briet M. Importance of arterial stiffness as cardiovascular risk factor for future development of new type of drugs.Fundam Clin Pharmacol, 2008,22(3):241-246.
[3] Avolio AP, Deng FQ, Li WQ, et al.Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension:comparison between urban and rural communities in China. Circulation,1985,71(2):202-210.
[4] Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness:methodological issues and clinical applications.Eur Heart J, 2006,27(21):2588-2605.
[5] Bolster BD Jr, Atalar E, Hardy CJ, et al. Accuracy of arterial pulse-wave velocity measurement using MR.J Magn Reson Imaging,1998,8(4):878-888.
[6] Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance:an integrated index of vascular function? Circulation,2002, 106(16):2085-1090.
[7] Wang X, Xie J, Zhang LJ, et al. Reference values of brachial-ankle pulse wave velocity for northern Chinese.Chin Med J,2009,122(18):2103-2106.
[8] Li B, Gao H, Li X, et al. Correlation between brachial-ankle pulse wave velocity and arterial compliance and cardiovascular risk factors in elderly patients with arterioscle-rosis ......
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