速度向量成像技术评价美沙酮维持治疗者左心室功能
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【摘要】 目的 应用速度向量成像技术(VVI)和常规超声心动图评价美沙酮维持治疗者左心室收缩功能,以探索早期反映心肌收缩功能异常的敏感性的指标。方法 30例健康者及30例美沙酮维持治疗者,取心尖四腔的速度向量图像,测定左室各节段的收缩期最大速度(Vp)、位移(D)、应变(S)及应变率(SR)。结果 ①超声心动图结果与对照组相比,处理组的左室整体功能无明显变化(P>0.05)。②VVI测量结果与对照组健康者相比,处理组美沙酮维持治疗者的左心室各节段的最大位移、速度均有所下降,应变、应变率显著下降(P<0.05),说明海洛因依赖者左室局部功能较正常人显著下降。结论 与常规测量左室功能的方法相比,速度向量成像技术能够客观、准确地评价海洛因依赖者的心肌运动功能,对临床诊治及判断预后具有重要的指导意义。
【关键词】 美沙酮;海洛因;左室功能;应变率
Evaluation of left ventricular function in MMT by velocity vector imaging
LIMing, PENG Yun-rong, LIU Li-hong,et al.
Shenzhen Longgang District Peoples Hospital,Shenzhen 518172,China
【Abstract】 Objective
Application of velocity vector imaging(VVI)and conventional echocardiographic indices evaluating left ventricular systolic function in heroin addicts, in order to explore the sensitivity indicators reflects the early systolic dysfunction. Methods 30 healthy persons and 30 cases of heroin addicts were studied at apical four-chamber view using VVI, the systolic peak velocity(Vp),systolic peak displacement(D),systolic peak strain rate(SR)and strain were measuredrespectively for each segment of both groups. Results ① The results of conventional echocardiography: compared with the control group, the left ventricular function in heroin addicts had no significant changes(P> 0.05).②The results of VVI: compared with A, in B group of all left ventricular segments, the maximum displacement, velocity had declined, strain, strain rate decreased significantly(P<0.05),this shown that regional left ventricular function in heroin addicts were significantly decreased compared with normal subjects. Conclusion Velocity vector imaging can objectively and accurately evaluate myocardial heroin motor function, it has important guiding significance on clinical diagnosis, treatment and prognosis.
【Key words】 Methadone;Heroin; Left ventricular function;Strain rate
海洛因为阿片受体兴奋剂,能强化交感神经,主要是肾上腺素能的活性,早期使心肌收缩力加强,晚期阿片物质通过调节中枢心血管功能,减弱心肌的正性变力性作用,从而对心脏功能产生影响[1,2]。本研究采用速度向量成像技术(VVI)和常规超声心动图,测定美沙酮维持治疗者左心室肌的应变、应变率等参数,从而定量评价美沙酮维持治疗者的左心室功能,比较两种测定方法,以探索早期反映心肌收缩功能异常的敏感性的指标,以指导临床诊治及预后判断。
1 资料与方法
1.1 一般资料
2009年1月至2009年7月期间在我们院美沙酮维持治疗门诊治疗的美沙酮维持治疗者(处理组 ......
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