奥扎格雷钠对急性脑梗死患者血清C反应蛋白与疗效的影响(1)
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【摘要】 目的 观察奥扎格雷钠对急性脑梗死(ACI)患者血清C反应蛋白(CRP)含量与疗效的影响。方法 136例急性脑梗死患者随机分为观察组和对照组各68例，对照组采用脑梗死常规治疗，观察组在常规治疗基础上加用奥扎格雷钠治疗，治疗前及14 d后测定CRP水平变化，并对神经功能缺损进行标准评分。结果 治疗后14 d观察组CRP水平较对照组降低，差异有统计学意义(P<0.05)，观察组神经功能缺损评分低于对照组，差异有统计学意义(P<0.05)。结论 奥扎格雷钠能降低ACI患者血清CRP水平，有利于减轻炎症反应，提高临床疗效。
【关键词】 奥扎格雷钠；C反应蛋白；脑梗死
Effect of sodium Ozagrel on C-reactive protein and clinical effectiveness in patients with acute cerebral infarction
ZHU Qi-cong, WANG Ya-hui, CHEN Ni-ka,et al.
Department of Third Medical 187 Hospital of PLA, Haikou,Hainan,571159,China
【Abstract】 ObjectiveTo investigate the effect of sodium Ozagrel on C-reactive protein(CRP) and clinical effectiveness in the patients with acute cerebral infarction(ACI).Methods 136 ACI patients were divided into two groups randomly.In observation group(n=68),sodium Ozagrel were given intravenously on the basis of conventional treatment.The conventional therapy was only used in the control group(n=68).The level of serum CRP and neurologic impairment scores(NIS) on pre-treatment and on the 14th day post-treatment were comparied in two groups.Results The serum level of CRP on the 14th day in observation group was significantly decreased than that in the control group(P<0.05).The decline of the NIS on the 14th day of the treatment was more striking in observation group than that in the control group(P<0.05).Conclusion Ozagrel can decrease serum level of CRP in ACI patient,which is favourable for subsidence of inflammatory reaction and improvement of clinical effectiveness.
【Key words】 Sodium Ozagrel；C-reactive protein(CRP)；Acute cerebral infarction(ACI)
脑梗死(acute cerebral infarction，ACI)是由脑血液供应障碍引起的局限性脑组织缺血性坏死或脑软化，是多因素作用的结果，治疗宜采取综合措施。C反应蛋白(C-reactive protein，CRP)是炎症标志物中最主要、最敏感的一种急性非特异性时相反应蛋白，临床研究已征实，血清CRP水平的升高与脑梗死发生有关[1]。奥扎格雷钠是一种高效强力的血栓素A2(thromboxane A2，TXA2)合成酶抑制剂，具有抗血小板聚集
作者单位：571159解放军第一八七医院内三科
和扩血管作用，近年来广泛用于急性缺血性脑梗死的治疗。本研究旨在观察奥扎格雷钠对ACI患者CRP与疗效的影响。
1 资料与方法
1.1 一般资料 全部资料系我院内三科2006年1月至2010年12月住院ACI患者，136例随机分为观察组和对照组，其中观察组68例，男37例，女31例，年龄38~88岁，平均(64.29±11.77)岁；对照组68例，男35例，女33例，年龄41~85岁，平均(65.34±10.03)岁。全部病例均符合以下条件:①1995年全国第四届脑血管病学术会议制定的诊断标准[2] ......
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