论文下载：肺炎支原体感染与儿童哮喘发病的关系(论著)

肺炎支原体感染与儿童哮喘发病的关系(1)

http://www.100md.com 2011年8月15日伍亚辉扬晓鸥刘翠梅盛珺戈志峰周韵娇管益芳

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     【摘要】目的探讨肺炎支原体(MP)感染与儿童哮喘(bronchial asthma in children)发病的关系。方法入选53例支气管哮喘患儿作为观察组，40例呼吸道感染患儿(包括肺炎及支气管炎)作为对照组，采用明胶颗粒凝集试验检测两组患儿血清肺炎支原体IgM(MPIgM)抗体，同时采用ELISA法和血球分析仪常规法测定支气管哮喘患儿血清总IgE水平和外周血嗜酸粒细胞计数。结果 53例支气管哮喘患儿中，有26例血MPIgM阳性，阳性率为49%；而40例对照组患儿中有7例血MPIgM阳性，阳性率为17.5%,两组比较差异有统计学意义(P<0.01)。MPIgM阳性的支气管哮喘患儿血清总IgE水平高于MPIgM阴性的支气管哮喘患儿(t=3.369,P=0.002)，MPIgM阳性的支气管哮喘患儿嗜酸粒细胞计数(EOS)高于MPIgM阴性的支气管哮喘患儿(t=8.548,P=0.001)，两组比较，差异有统计学意义(P<0.01)。结论肺炎支原体感染与儿童哮喘有密切相关性。

    【关键词】

    肺炎支原体感染；小儿；哮喘

    

    Correlation between mycoplasma pnenumonia infection and bronchial asthma in children

    WU Yahui， YANG Xiaoou, LIU Cuimei, et al. Min hang Wu jing Hospital of Shanghai，Shanghai 200241,China

    

    【Abstract】 Objective

    To determine the relationship between mycoplasma pnenumonia (MP) infection and bronchial asthma in children. Methods 53 children with bronchial asthma were selected as the experiment group and 40 children with acuterespiratory infection(including pneumonia and bronchitis) as the control group.The MPIgM antibody level was determined by particle agglutination method in both groups and total serum IgE level determined by ELISA in the bronchial asthma group.The count of eosinophils(EOS) was detected by blood cell analyzer in the bronchial asthma group. Results 26 cases were determ ined as MpIgM positive in bronchial asthma group and 7 cases in the controls.the positive rates of MpIgM were 49% and 17.5% respectively.There was significantly difference (P<0.01)between two groups.The total serum IgE level was markedly higher in MPIgM positive bronchial asthma children than in the MPIgM negative bronchial asthma children(t=3.369,P=0.002). The count of Eosinophics in MPIgM positive bronchial asthma children was more than in MPIgM negative bronchial asthma children(t=8.548,P=0.001) with remarkablesignificant difference (P<0.01).Conclusion There is close relationship between mycoplasma pnenumonia (MP) infection andbronchial asthmainchildren.

    【Key words】

    Mycoplasma pnenumonia infection； Children; Bronchial asthma in children ......

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