氨溴索治疗小儿毛细支气管炎的临床研究(1)
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【摘要】 目的 探讨氨溴索治疗小儿毛细支气管炎的临床疗效。方法 本文采用氨溴索超声雾化吸入治疗毛细支气管炎患儿，并与常规治疗的对照组进行疗效对比。结果 对两组患儿的临床治疗效果进行统计分析发现治疗组的痊愈率和有效率均明显高于对照组(P<0.05)。另外，治疗组患儿的气促缓解、心率正常方面与对照组相比差异无统计学意义(P>0.05)；而治疗组患儿的哮鸣音、湿啰音、咳嗽等临床特征消失时间与对照组相比差异有统计学意义(P<0.05)。结论 在婴幼儿毛细支气管炎急性期采用盐酸氨溴索雾化吸入的治疗可以明显改善患儿的临床症状、疗效显著、缩短病程、副作用轻微，值得临床推广使用。
【关键词】
氨溴索；治疗；小儿毛细支气管炎
Clinical study of Ambroxol in treating children with bronchiolitis
ZHANG Hongyi.
Department of Pharmary,Shuangdian Center Hospital of Donghai Country in Jiangsu 222331，China
作者单位：222331江苏省东海县双店中心卫生院药剂科
【Abstract】 Objective
To investigate the clinical effect of Ambroxol in treating children with bronchiolitis. Methods In this paper, ultrasonic atomizing inhalation of Ambroxol was used in treatment of children with bronchiolitis, and compared its clinical effect with the control group which was treated with traditional method. Results By using statistical analysis, the cure rate and effective rate were all significantly higher than the control group (P<0.05). In addition, the treatment group children relieve shortness of breath, heart rate, with the normal control group showed no significant difference (P>0.05). The treatment group of children with wheeze disappeared, moist rales disappeared, disappearance of the clinical characteristics of cough significant difference compared with the control group, and the difference was statistically significant (P<0.05). Conclusion In infants with acute bronchiolitis, Ambroxol hydrochloride inhalation therapy can significantly improve clinical symptoms in children, has a significant effect, can shorten the course, and has little side effect. So it is worthy of clinical use.
【Key words】
Ambroxol; Treatment; Children with bronchiolitis
我院儿科于2010年1月至2011年5月对收治的毛细支气管炎患儿采用氨溴索治疗毛细支气管炎患儿，取得了良好的临床疗效，现将结果报告如下。
1 资料与方法
1.1 一般资料 2010年1月至2011年5月选择在我院接受治疗的毛细支气管炎患儿40例，其中男23例，女17例；入选的患儿均于发病3 d内收治入院，且人院时所有患儿的临床症状主要有：阵发性咳嗽、喘憋、气促，心率快，肺部有哮鸣音及小水泡音；排除呼吸衰竭、心力衰竭等并发症；排除先天性心脏病及严重的佝偻病患儿。年龄6~20个月，平均(11.8±6.6)个月。
1.2 方法 按照序贯法将40例毛细支气管炎患儿随机分为治疗组和对照组，每组各20例，两组患儿的年龄、性别、发病时间等比较差异无统计学意义(P>0.05) ......
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