进展期胃癌术中行区域性缓释化疗的安全性评价(1)
 |
| 第1页 |
参见附件(2792KB，2页)。
【摘要】目的探讨进展期胃癌术中腹腔内行区域性植入5氟尿嘧啶缓释化疗的临床疗效及用药安全进行分析评价。方法将60例进展期胃癌患者均进行手术根治切除术后并随机分为两组，治疗组：30例患者给予术中行区域性缓释化疗；对照组30例患者与治疗组患者术后均进行常规全身化疗，并对其两组患者治疗后临床疗效进行疗效评价及安全性评价。结果疗效判定治疗组：完全缓解8例占267%、部分缓解11例占367%、疾病稳定7例占233%、疾病进展4例占133%。对照组：完全缓解5例占17%、部分缓解9例占300%、疾病稳定11例占367%、疾病进展5例占167%。两组患者在治疗后腹腔相关并发症与化疗毒副作用无显著差异。结论进展期胃癌术中腹腔内行区域性植入5氟尿嘧啶缓释化疗，患者耐受性良好，用药后临床疗效增加而未见明显的全身、局部不良反应。
【关键词】进展期胃癌；区域缓释化疗；5氟尿嘧啶缓释剂；疗效评价；不良反应
Advanced gastric cancer intraoperative regional safety evaluation of sustainedrelease chemotherapyHE Xingchang.Departmetn of General Surgery The First Peoples Hospital of Shangqiu city 476100,China
【Abstract】ObjectiveTo discuss advanced gastric cancer implanted in the abdominal cavity of regional experts 5Fluorouracil chemotherapy efficacy and sustainedrelease drug safety analysis and evaluationMethods60 cases of advanced gastric cancer patients underwent radical surgical resection were randomly divided into treatment groups:30 patients were treated with intraoperative regional slowrelease chemotherapy,control group of 30 patients with treatment group patientsare routine chemotherapy, and two groups of patients after their clinical efficacy evaluation and safety evaluationResultsDetermine the efficacy of the treatment groups:complete remission in 8 cases accounted for 267%, partial response 11 cases accounted for 367%, seven cases of stable disease 233%, disease progression was four cases (133%)Control group:5 cases were (17%) complete remission, partial remission in 9 cases accounted for 300%, stable disease 11 cases accounted for 367%, disease progression, five cases of 167%Two groups of patients after abdominalrelated complications in the treatment of chemotherapy side effects with no significant differenceConclusionAdvanced gastric cancer surgery in the abdominal cavity implantation of regional experts 5Fluorouracil sustainedrelease chemotherapy, the patient is well tolerated, clinical efficacy after treatment no significant increase in systemic and local adverse reactions.
【Key words】Advanced gastric cancer; Regional release chemotherapy; 5Fluorouracil release agent; Evaluation; Adverse reactions ......
您现在查看是摘要介绍页，详见PDF附件(2792KB，2页)。