2型糖尿病患者颈动脉及下肢动脉硬化与冠状动脉疾病的关系(1)
 |
| 第1页 |
参见附件(3164KB，3页)。
【摘要】 目的 分析2型糖尿病合并冠心病的危险因素及其与颈动脉及下肢动脉粥样硬化的相关性。方法 将200例2型糖尿病患者分为冠心病组及非冠心病组，均接受颈动脉及下肢动脉血管彩超检查，并记录两组临床资料及实验室数据，分析冠心病的危险因素及与动脉粥样硬化的关系。结果 ①单因素分析发现年龄、病程、收缩压、总胆固醇、尿素氮、肌酐、尿微量白蛋白、24 h尿总蛋白、高血压病史及脑梗死史，以及颈动脉、下肢动脉粥样硬化与糖尿病合并冠心病的发病呈正相关， P<0.05。②多因素分析提示颈动脉及下肢动脉粥样硬化是糖尿病合并冠心病的独立危险因素，其OR值分别为1.841 (95%CI:1.117, 3.033)和2.409 (95%CI:1.659, 3.497)。结论 颈动脉及下肢动脉粥样硬化与2型糖尿病合并冠心病密切相关，其预测冠心病能力较传统危险因素强。
【关键词】 糖尿病；动脉粥样硬化；冠心病；超声检查；彩色多普勒
Relationgship of atherosclerosis in carotid and lower limbs arteries to coronary artery disease in type 2 diabetes LI Ya-qing，ZHANG Jia-jun， LIN Jian-cai. Department of Endocrinology,Jiangmen Central Hospital,Jiangmen 529100,China
【Abstract】 Objective To analyze the risk factors of coronary heart disease (CHD) with type 2 diabetes mellitus, and to explore the relationship between carotid artery, lower limbs artery atherosclerosis and coronary disease. Methods 200 patients with type 2 diabetes mellitus were divided into CHD group and non CHD group, and accepted the carotid artery and lower limbs arterial color Dopplar ultrasound examination. Two groups of clinical data and laboratory data were recorded, to analyze the risk of CHD factors and the relationship with atherosclerosis. Results ①Single factor analysis found that age, duration, systolic blood pressure, total cholesterol, urea nitrogen, serum creatinine, urine albumin, 24 h urine trace total protein, history of hypertension, cerebral infarction history, and the carotid artery, lower limbs artery atherosclerosis were positively related with CHD combined with diabetes, P< 0.05.②Multivariate analysis showed that carotid and lower limbs atherosclerosis are independent risk factors for CHD with diabetes, the OR values were 1.841 (95% CI:1.117, 3.033) and 2.409 (95% CI:1.659, 3.497).Conclusion Carotid artery and lower limbs atherosclerosis is closely related with diabetes mellitus with CHD, which of the forecasting ability for CHD is stronger than the traditional risk factors.
【Key words】 Diabetes mellitus; Atherosclerosis; Coronary disease; Ultrasonography; Color Doppler
近年来研究表明，颈动脉粥样硬化(CAS)与冠状动脉粥样硬化密切相关[1]，但在糖尿病的患者中下肢动脉硬化(LLAS)与冠心病的相关研究少见。本研究通过对我院200例2型糖尿病患者进行颈动脉及下肢动脉血管彩超检查，从而进一步探讨2型糖尿病患者颈动脉及下肢动脉与冠状动脉疾病的关系。现报告如下。
1 资料与方法
1.1 一般资料 选取2008年至2011年在我院住院的2型糖尿病患者200例，记录所有患者的冠状动脉疾病病史情况，包括有无心肌梗死，冠脉介入或搭桥术后，无上述冠状动脉疾病者均行64排螺旋冠脉CT检查，CT提示至少一支冠状动脉狭窄≥50%者诊断为冠心病[2]。根据冠状动脉疾病情况分为冠心病组和非冠心病组。其中冠心病组102例 ......
您现在查看是摘要介绍页，详见PDF附件(3164KB，3页)。