抗心磷脂抗体和抗β2-GP1抗体与子痫前期的相关性研究(1)
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【摘要】 目的 探讨抗心磷脂抗体和抗β2-GP1抗体与子痫前期发病的关系。方法 对30例子痫患者及30例同期住院分娩的正常孕妇，用ELISA法定量检测其母血血清抗心磷脂抗体和抗β2-GP1抗体的滴度值。结果 子痫前期患者ACA-IgG、IgM 和抗β2-GP1抗体的阳性率显著高于正常对照组(P<0.05),正常对照及轻、重子痫前期三组孕妇血清ACA-IgG、IgM 和抗β2-GP1抗体的滴度值差异有统计学意义(P<0.05)。结论 子痫前期患者母血ACA-IgG、IgM 和抗β2-GP1抗体的阳性率、滴度值显著高于正常对照组，提示抗心磷脂抗体和抗β2-GP1抗体可能参与了子痫前期的发生发展过程，与子痫前期的发病具有相关性，孕期检测抗心磷脂抗体和抗β2-GP1抗体对预测子痫前期患者疾病发展有重要价值，为子痫前期的诊断与治疗提供了新的途径。
【关键词】 抗心磷脂抗体；抗β2-GP1抗体；子痫前期
Preeclampsia correlation study between Anticardiolipin antibody and antiβ2-GP1 antibody ZHOU Yong-qing.Department of gynecology and obstetrics Henan province Guangshan County，People’s Hospital,Henan 465400,China
【Abstract】 Objective To investigate the anticardiolipin antibodies and anti β2-GP1 antibody and the pathogenesis of preeclampsia relationships. Methods 30 cases of eclampsia patients and 30 cases of normal pregnant women hospitalized earlier delivery, using ELISA method to quantitatively detect the maternal serum anticardiolipin antibody and anti β2-GP1 antibody titer values. Results In patients with preeclampsia ACA-IgG, IgM and antiβ2-GP1 antibody positive rate of beta was significantly higher than that in normal control group (P<0.05), the normal control and light, baryon preeclampsia in three groups of maternal serum ACA-IgG, IgM andβ2-GP1 antibody titer values of beta difference was statistically significant (P<0.05). Conclusion patients with preeclampsia in maternal serum ACA-IgG,IgM and β2-GP1antibody positive rate of beta, titer values were higher than those in normal control group, tips of anticardiolipin antibody and antiβ2-GP1 antibody may be involved in the occurrence and development of preeclampsia, and preeclampsia incidence has relevance, pregnancy testing anticardiolipin antibody and β2-GP1antibody to predict preeclampsia beta patients with early disease development has important value for preeclampsia, diagnosis and therapy provides a new way.
【Key words】 Anticardiolipin antibody;Antiβ2-GP1 antibody; Preeclampsia
妊娠期高血压疾病是病例妊娠中常见的一种疾病。本病是于妊娠20周后首次发生高血压、蛋白尿及水肿，可合并多器官功能衰竭、DIC、胎儿宫内生长受限、胎儿宫内窘迫、死亡等并发症。发病原因至今尚未完全阐明，多数学者认为其发病与血液高凝状态有关。为探讨ACA、抗β2-GP1抗体与子痫前期发病的相关性，我们做了以下研究，现将结果报道如下。
1 资料与方法
1.1 一般资料 选择 2008-02至2011-02于我院住院分娩的30例子痫前期患者(子痫前期组) ......
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