哮喘清合剂联合小剂量西药防治小儿支气管哮喘发作的临床研究(1)
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【摘要】 目的 探讨哮喘清合剂联合小剂量西药防治小儿支气管哮喘发作的临床疗效。方法 选择2010年1月至2011年7月间在我院就诊治疗的小儿支气管哮喘患者100例，随机分为2组，实验组50例，口服哮喘清合剂加用小剂量西药；对照组50例，吸入糖皮质激素和(或)孟鲁斯特钠咀嚼片，观察3个月为一个疗程。同时在发作期、缓解期及一个疗程结束后分别作嗜酸粒细胞计数(EOS)、呼出气一氧化氮检测(FeNO)及肺功能观察不同时期的变化。比较两组的总有效率。结果 实验组与对照组的总有效率分别为94.0%、74.0%，两组总有效率比较差异有统计学意义(P<0.05)。观察各指标间差异有统计学意义。结论 哮喘清合剂联合小剂量西药可以快速防治小儿支气管哮喘的发作控制病情及各指标改善明显，提高了总有效率。
【关键词】 哮喘清合剂；小儿支气管哮喘；呼出气一氧化氮；肺功能；嗜酸粒细胞计数
Clear mixture combined with low dose of asthma medicine in children with bronchial asthma prevention and control clinical study LI Qiong, WANG Shu,hua, FENG Ji,fang, et al.Hebei Hengshui City, Halixun International Peace Hospital of Henshui city，Hengshui 053000,China
【Abstract】 Objective To investigate the clear mixture combined with low dose of asthma medicine in children with bronchial asthma prevention and treatment of clinical efficacy. Methods January 2010 May 2011 in our hospital treated 100 cases of bronchial asthma, were randomly divided into two groups, experimental group of 50 patients, oral asthma clear mixture with a small dose of medicine; control group of 50 patients, inhaled corticosteroids, and (or) montelukast sodium chewable tablets Manchester, observed for 3 months for a course of treatment. While in the attack, and a remission after treatment, respectively, for eosinophil count (EOS), exhaled nitric oxide (FeNO) and changes in lung function observed in different periods. The total effective rate were compared. Results Experimental group and control group the total effective rate was 94.0%, 74% by t test, total effective there was a significant difference (P<0.05). Observe statistically significant differences among the indicators. Conclusion Clear mixture combined with low dose of asthma medicine can quickly control the onset of bronchial asthma in children and the control of the disease indicators improved significantly improve the total efficiency.
【Key words】 Asthma clear mixture；Bronchial asthma in children；Exhaled nitric oxide；Lung function；Eosinophil count
支气管哮喘属中医“哮证”范畴，从临床特征来看，无论先天因素还是后天因素，均是肺脾肾三脏不足，而形成痰气内伏的特殊体质，每遇外邪引动伏痰而发作哮喘。经临床长期观察，筛选出黄芪、黄芩、炙麻黄、地龙、蝉衣、甘草、当归、川贝母、橘红、黄精、白术等健脾益气，化痰平喘中药，组成哮喘清合剂，防治小儿哮喘有良好的效果，值得进一步研究。对此我们进行了实验，取得较好效果，现报告如下。
1 资料与方法
1.1 一般资料
1.1 ......
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