两种不同剂量A型肉毒毒素治疗偏头痛的疗效观察(2)
本研究采用了50 U、100 U两种不同剂量BTXA，选取了额肌、颞肌、枕下区、头夹肌、头半棘肌共12个注射位点，正在服用预防性药物、普通止痛类药物的患者可继续服药。结果发现两组均能有效减轻偏头痛患者的头痛程度、减少发作频率、提高生活质量；100 U BTXA对头痛程度的减轻优于50 U BTXA，头痛发作频率、生活质量的改善与剂量无关。两组均不良反应轻微。以后的研究应扩大样本量，长时间多次注射进行观察。
参 考 文 献[1] Binder WJ, Brin MF, Blitzer A, et alBotulinum toxin type A (BOTOX) for treatment of migraine headaches: an openlabel studyOtolaryngol Head Neck Surg, 2000 Dec,123(6):66976.[2] Welch MJ, Purkiss JR, Foster KA Sensitivity of embryonic rat dorsalroot ganglia neurons to Clostridium botulinum neurotoxins Toxicon,2000,38(2):24558.[3] Aoki KR Evidence for antinociceptive activity of botulinum toxin type A in pain managementHeadache,2003,43(suppl 1):S9S15.[4] Durham PL， Cady R， Cady RRegulation of calcitonin generelated peptide secretion from trigeminal nerve cells by botulinum toxin type A： implications for migraine therapyHeadache， 2004，44(1)：3542.[5] Suzuki K, Iizuka T, Sakai FBotulinum toxin type A for migraine prophylaxis in the Japanese population: an openlabel prospective trialIntern Med, 2007,46(13):95963.[6] Silberstein S, Mathew N, Saper J, Jenkins S Botulinum toxin type A as a migraine preventive treatment For the BOTOX Migraine Clinical Research Group Headache, 2000,40(6):44550, 百拇医药(成爱霞)
参 考 文 献[1] Binder WJ, Brin MF, Blitzer A, et alBotulinum toxin type A (BOTOX) for treatment of migraine headaches: an openlabel studyOtolaryngol Head Neck Surg, 2000 Dec,123(6):66976.[2] Welch MJ, Purkiss JR, Foster KA Sensitivity of embryonic rat dorsalroot ganglia neurons to Clostridium botulinum neurotoxins Toxicon,2000,38(2):24558.[3] Aoki KR Evidence for antinociceptive activity of botulinum toxin type A in pain managementHeadache,2003,43(suppl 1):S9S15.[4] Durham PL， Cady R， Cady RRegulation of calcitonin generelated peptide secretion from trigeminal nerve cells by botulinum toxin type A： implications for migraine therapyHeadache， 2004，44(1)：3542.[5] Suzuki K, Iizuka T, Sakai FBotulinum toxin type A for migraine prophylaxis in the Japanese population: an openlabel prospective trialIntern Med, 2007,46(13):95963.[6] Silberstein S, Mathew N, Saper J, Jenkins S Botulinum toxin type A as a migraine preventive treatment For the BOTOX Migraine Clinical Research Group Headache, 2000,40(6):44550, 百拇医药(成爱霞)