盐酸法舒地尔对急性脑梗死患者血清超敏C反应蛋白和血管内皮生长因子的影响(1)
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【摘要】目的 观察盐酸法舒地尔对急性脑梗死患者血清超敏C反应蛋白和血管内皮生长因子的影响。 方法 86例急性脑梗死患者随机分为两组，治疗组46例，对照组40例。对照组采用常规治疗，治疗组在常规治疗基础上加用法舒地尔，共观察21 d。治疗前后测定血清超敏C反应蛋白(hs-CRP)和血管内皮生长因子(VEGF)。 结果 两组在治疗7、21 d后神经功能均有明显好转，并且治疗组改善程度在7、21 d均优于对照组( P <0.05)。两组在治疗后hs-CRP和VEGF均有显著降低，并且治疗组降低程度更明显( P <0.05)。 结论 法舒地尔可以减少急性脑梗死患者hs-CRP和VEGF的表达，从而改善病情。
【关键词】 脑梗死；法舒地尔；超敏C反应蛋白；血管内皮生长因子
The effectiveness of fasudil on hs-CRP and VEGF of patients with acute cerebral infarction WANG Fang, LIU Ai-zhong. The Marine Hospital in Yantai,Shandong 264000,China
【Abstract】 Objective
To study the effectiveness of fasudil on high sensitivity C-reactive protein(hs-CRP) and vascular endothelial growth factor(VEGF)of patients with acute cerebral infarction. Methods Eighty-six patients with acute cerebral infarction were randomly divided into two groups,the control group(n=40 cases) and the treatment group(n=46 cases).The patients in the control group were treated through conventional treatment and the treatment group through conventional plus fasudil treatment.They were treated for twenty-one days.The hs-CRP and VEGF were detected before and after treatment. Results The nerve function were improved after treatment for both groups,moreover the nerve function in the treatment group was better than that in the control group( P <0.05).hs-CRP and VEGF in both groups were decreased after treatment.There was a significant difference between two groups( P <0.05). Conclusion Fasudil could decrease hs-CRP and VEGF of patients with acute cerebral infarction.
【Key words】 Cerebral infarction; fasudil; hs-CRP; VEGF
脑梗死由于其发病率高、致残率更高，严重威胁人类健康。在治疗上目前有溶栓、抗血小板聚集、抗凝、脑保护治疗等[1]。目前溶栓虽为首选治疗，但由于其严格的时间窗、适应证、禁忌证及可能导致的严重并发症，许多患者未能受益。如何保护受损神经元成为研究的热点 ......
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