尤瑞克林治疗急性脑梗死的疗效及安全性观察(1)
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【摘要】目的观察尤瑞克林治疗急性脑梗死的疗效及安全性。方法2009年1月至2011年2月我科收治的急性脑梗死患者128例，随机分为尤瑞克林治疗组(n=64)和对照组(n=64)，分别观察治疗前后神经功能缺损程度(NIHSS)评分，残障评分(MRS)，并随访90 dMRS。结果治疗后，两组患者NIHSS和MRS评分均降低(P<005)，尤瑞克林治疗组NIHSS，MRS及总有效率均优于对照组(P<005),治疗组90 dMRS与治疗结束相比显著降低，与对照组90 dMRS相比也显著降低(P<001)。结论尤瑞克林治疗急性脑梗死可显著提高患者的生活质量，改善神经功能缺损状况，降低致残率，且安全性好，值得临床推广。
【关键词】尤瑞克林;急性脑梗死;有效性;安全性
The observation of the effect of urinary kallidinogenase in treatment of acute cerebral infaretion efficary and safetyWANG Lingmin,XU Xiaoning,WANG Yongheng,et al.Xichuan second people’s hospital,Xichuna 474450,China
【Abstract】ObjectiveTo obseve the effect of urinary kallidinogenase in treatment of acute cerebral infaretion efficary and safetyMethodsfrom 2009 Janurary to 2011 February in our department in 128 patients with acute cerebral in farction were randomly divided into treatment group,Yurek Lin(n=64) and control group (n=64) were observed before and after the treatment,the degree of neural function defect score(NIHSS),disability score(MRS),MRS and followed up for 90 daysResultsAfter treatment,Two groups of patients With NIHSSand MRS were decreased(P<005),urinary kallidinogenase treatment groups NIHSS,MRS and the total effective rate were better than the controlgroup(P<005),treatment group90 days MRS and the end of treatment group 90 days MRS and the end of treatment significantly lower,compared with acontrol group of 90 days compared to MRS also decreased sogificantly(P<001)ConclusionYurek Lin in treatment of acute cerebral infarction can obviously improve the quality of life of pantients,improve nellrologic deficit condition,reduce the disiablitity rate,cutting safety good,worthy of dinical applicationd.
【Key words】Urinary Kallidimogenase; Acllte cerebral infarction;Effectiveness;Safety
作者单位：474450河南省淅川县第二人民医院
通讯作者：徐小宁急性脑梗死又称缺血性脑卒中，是指脑局部供血区血流减少或中断，引起脑组织缺血缺氧，神经细胞变性坏死，出现相应的神经系统症状和体征，其发病率致残率病死率均较高，给家庭及社会带来沉重的负担，早期的治疗关键是恢复梗死区血供，抢救缺血半暗带，减轻灌注损伤和抑制血小板聚集。近年来采用溶栓治疗取得良好效果，但有严格的6 h治疗时间窗[12],且存在脑出血等严重不良反应 ......
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