【摘要】 主要阐述血清甲胎蛋白(AFP)在肿瘤诊断中的鉴别意义。说明AFP对肝细胞癌的临床诊断价值为各种诊断方法中专一性仅次于病理检查的诊断方法, 为目前最好的早期诊断方法之一。对年轻男性, 前纵隔肿块伴AFP或/和HCG水平升高者, 可诊断为纵隔非精原细胞瘤。睾丸癌AFP检测的价值在于患者的临床症状和其他的诊断程序相结合时, 诊断非精原细胞瘤睾丸癌。AFP是开放性神经管缺陷及唐氏综合征的标记物。

    【关键词】 血清甲胎蛋白；肝癌；纵隔恶性生殖细胞瘤；睾丸癌

    Significance of maternal serum alpha-fetoprotein in differential diagnosis of tumor XING Jian-jun, MIAO Yang. Tonghua Central Hospital, Tonghua 134001, China

    【Abstract】 To state significance of maternal serum alpha-fetoprotein(AFP)in the differential diagnosis of tumor. Clinical application had proved that the AFP was the best diagnostic method secondary to pathological examination for hepatocellular carcinoma(HCC), which was one of the best early diagnostic methods. For young men, the former mediastinal mass with increasing AFP and/or HCG levels can be diagnosed with mediastinal seminoma, generally do not need regular biopsy confirmed. The value of testicular cancer AFP detection is that the combination of clinical symptoms and other diagnostic procedures help to diagnose non seminoma testicular cancer. AFP is an open neural tube defects and markers for down syndrome. ......
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    邢建军 苗阳 吉林省通化市中心医院肿瘤二科;

    【摘要】主要阐述血清甲胎蛋白(AFP)在肿瘤诊断中的鉴别意义。说明AFP对肝细胞癌的临床诊断价值为各种诊断方法中专一性仅次于病理检查的诊断方法,为目前最好的早期诊断方法之一。对年轻男性,前纵隔肿块伴AFP或/和HCG水平升高者,可诊断为纵隔非精原细胞瘤。睾丸癌AFP检测的价值在于患者的临床症状和其他的诊断程序相结合时,诊断非精原细胞瘤睾丸癌。AFP是开放性神经管缺陷及唐氏综合征的标记物。

    【关键词】 血清甲胎蛋白 肝癌 纵隔恶性生殖细胞瘤 睾丸癌

    【分类号】R730.4

    1956年Bergstrand和Czar在人胎儿血清中发现一种胚胎专一性甲种球蛋白,现称甲胎蛋白(alpha fetoprotein,AFP)。1964年,Tatarinov在肝细胞癌患者血中测得AFP。这一现象在20世纪60年代末和70年代初得到反复验证,并用于临床和肝癌普查。1971年,Abelev对AFP做了全面总结[1]。AFP是