【摘要】 目的 讨论12种肿瘤标志物蛋白芯片检测系统(C-12)在肿瘤筛查的应用。方法 采用C-12型多肿瘤标志物蛋白芯片检测试剂盒检测1950例健康体检者及336例住院患者血清中12种肿瘤标志物的水平， 结合临床情况， 分析比较检出阳性率和临床肿瘤诊断符合率。结果 健康体检者C-12检测指标阳性率5.13%低于住院患者26.49%(P<0.05)；阳性健康体检者肿瘤检出率56.52%与阳性住院患者79.78%比较差异具有统计学意义(P<0.05)；蛋白芯片检测结果阳性者与临床诊断肿瘤者其符合率达71.85%。结论 多肿瘤标志物蛋白芯片检测系统是肿瘤高危人群筛查的重要手段， 可用于临床肿瘤的辅助诊断、预后及疗效观察。

    【关键词】 多肿瘤标志物；蛋白芯片；肿瘤；筛查

    DOI：10.14163/j.cnki.11-5547/r.2016.25.001

    【Abstract】 Objective To discuss application of multi-tumor marker protein chip detection system (C-12) in tumor screening. Methods C-12 multi-tumor marker protein chip detection kit was applied to detect 12 serum tumor markers levels in 1950 healthy people and 336 hospitalized patients. Analysis was made in accordance with their clinical situation on positive rate and clinical tumor diagnostic accordance rate. Results Healthy people had lower C-12 indexes positive rate as 5.13% than 26.49% in hospitalized patients (P<0.05). The difference of tumor detection rate between 56.52% in positive healthy people and 79.78% in positive hospitalized patients had statistical significance (P<0.05). Coincidence rate was 71.85% between positive cases in protein chip detection and cases with tumor by clinical diagnosis. Conclusion As an important screening method for tumor high risk group ......