经颅多普勒屏气试验研究脑血管储备功能对中度血管性痴呆预后的影响(1)
【摘要】 目的 分析经颅多普勒屏气试验研究脑血管储备功能对中度血管性痴呆(VD)预后的影响。方法 60例中度VD患者， 其中30例伴大脑中动脉狭窄的中度VD患者设为MCASVD组， 30例无顱内动脉狭窄的中度VD患者设为无狭窄VD组， 并选择同期健康体检者30例作为对照组， 选择经颅多普勒屏气试验对研究对象的平均峰值流速(Vm)上升率、屏气指数(BHI)和简易精神状态量表(MMSE)评分进行测定， 6个月后对三组研究对象上述指标进行测定。结果 6个月后MCASVD组患者、无狭窄VD组患者的MMSE评分分别为(15.16±2.23)、(16.16±1.18)分， 显著低于入组时的(16.35±2.02)、(17.15±2.21)分， 且低于对照组同时间MMSE评分差异有统计学意义(P<0.05)。6个月后MCASVD组患者和无狭窄VD组患者的BHI、Vm上升率降低， 分别为(0.61±0.22)、(14.37±4.05)%和(1.08±0.21)、(25.54±5.27)%， 与入组及对照线同时间比较， 比差异有统计学意义(P<0.05)。结论 脑血管储备功能降低和中度VD的发生、发展有直接关系， 可以将其作为评估中度VD患者预后的主要指标。
【关键词】 经颅多普勒屏气试验；脑血管储备功能；中度；血管性痴呆；预后
DOI：10.14163/j.cnki.11-5547/r.2016.33.020
Influence by transcranial Doppler breath-holding test in research of cerebrovascular reserve capacity on prognosis of moderate vascular dementia LUO De-hong， LIN Tao， LIN Hui-xian. Department of Neurology， Yangjiang City Affiliated People’s Hospital of Guangdong Medical College， Yangjiang 529500， China
【Abstract】 Objective To analyze influence by transcranial Doppler breath-holding test in research of cerebrovascular reserve capacity on prognosis of moderate vascular dementia (VD). Methods Among 60 moderate VD patients， 30 moderate VD patients with complicated middle cerebral artery stenosis were taken as MCASVD group， and the other 30 moderate VD patients without intracranial arterial stenosis were taken as non-stenosis VD group. Another 30 healthy people were taken as control group. Transcranial Doppler breath-holding test was applied to detect mean peak velocity (Vm) escalating rate， breath-holding index (BHI) and mini-mental state examination (MMSE) score in all study subjects， and above indexes were redetected in 6 months. Results After 6 months， MCASVD group and non-stenosis VD group had MMSE score respectively as (15.16±2.23) and (16.16±1.18) points， which were all much lower than (16.35±2.02) and (17.15±2.21) points at admission and score in the control group， and their difference had statistical significance (P<0.05). After 6 months， MCASVD group and non-stenosis VD group had lowered BHI and Vm escalating rate， respectively as (0.61±0.22)， (14.37±4.05)% and (1.08±0.21)， (25.54±5.27)%. Their difference with those at admission and in the control group had statistical significance (P<0.05). Conclusion decreased cerebrovascular reserve capacity is directly related with occurrence and progress of moderate VD， and it can be taken as the main index for evaluating prognosis of moderate VD patients.
【Key words】 Transcranial Doppler breath-holding test； Cerebrovascular reserve capacity； Moderate； Vascular dementia； Prognosis, 百拇医药(罗德宏 林涛 林惠贤)
【关键词】 经颅多普勒屏气试验；脑血管储备功能；中度；血管性痴呆；预后
DOI：10.14163/j.cnki.11-5547/r.2016.33.020
Influence by transcranial Doppler breath-holding test in research of cerebrovascular reserve capacity on prognosis of moderate vascular dementia LUO De-hong， LIN Tao， LIN Hui-xian. Department of Neurology， Yangjiang City Affiliated People’s Hospital of Guangdong Medical College， Yangjiang 529500， China
【Abstract】 Objective To analyze influence by transcranial Doppler breath-holding test in research of cerebrovascular reserve capacity on prognosis of moderate vascular dementia (VD). Methods Among 60 moderate VD patients， 30 moderate VD patients with complicated middle cerebral artery stenosis were taken as MCASVD group， and the other 30 moderate VD patients without intracranial arterial stenosis were taken as non-stenosis VD group. Another 30 healthy people were taken as control group. Transcranial Doppler breath-holding test was applied to detect mean peak velocity (Vm) escalating rate， breath-holding index (BHI) and mini-mental state examination (MMSE) score in all study subjects， and above indexes were redetected in 6 months. Results After 6 months， MCASVD group and non-stenosis VD group had MMSE score respectively as (15.16±2.23) and (16.16±1.18) points， which were all much lower than (16.35±2.02) and (17.15±2.21) points at admission and score in the control group， and their difference had statistical significance (P<0.05). After 6 months， MCASVD group and non-stenosis VD group had lowered BHI and Vm escalating rate， respectively as (0.61±0.22)， (14.37±4.05)% and (1.08±0.21)， (25.54±5.27)%. Their difference with those at admission and in the control group had statistical significance (P<0.05). Conclusion decreased cerebrovascular reserve capacity is directly related with occurrence and progress of moderate VD， and it can be taken as the main index for evaluating prognosis of moderate VD patients.
【Key words】 Transcranial Doppler breath-holding test； Cerebrovascular reserve capacity； Moderate； Vascular dementia； Prognosis, 百拇医药(罗德宏 林涛 林惠贤)