普拉克索与美多芭联合应用治疗帕金森病的疗效观察(1)
【摘要】 目的 觀察普拉克索联合多巴丝肼片(商品名：美多芭)治疗帕金森病的治疗效果。方法 118例帕金森病患者， 随机分为对照组(60例)和观察组(58例)。对照组患者采取单纯美多芭治疗， 观察组患者采取美多芭联合普拉克索治疗， 观察两组患者的临床疗效， 治疗前后对患者进行帕金森病统一评分量表(UPDRS)和帕金森病病情评估量表(Webster)测评。结果 两组治疗后Hoehn-Yahr分期均较治疗前改善， 且观察组改善程度优于对照组， 差异均具有统计学意义(P<0.05)。两组治疗后UPDRSⅡ与Ⅲ的评分均低于治疗前， 且观察组低于对照组， 差异均具有统计学意义(P<0.05) 。观察组总有效率为96.6%， 高于对照组的70.0%， 差异有统计学意义(P<0.05)。观察组不良反应发生率为13.8%， 低于对照组的30.0%， 差异有统计学意义(P<0.05)。结论 美多芭联合普拉克索治疗帕金森病的临床效果显著优于单独应用美多芭， 可有效改善帕金森病患者的临床症状， 减少用药后异动症及药物不良反应的发生， 值得推广应用。
【关键词】 帕金森病；普拉克索；多巴丝肼片
DOI：10.14163/j.cnki.11-5547/r.2017.01.046
Observation on curative effect of pramipexole combined with Madopa for the treatment of Parkinson’s disease ZHANG Yan-li， LI Yan， LIANG Qian， et al. Department of Neurology， Dalian University Affiliated Zhongshan Hospital， Dalian 116000， China
【Abstract】 Objective To observe treatment effect of pramipexole combined with levodopa and benserazide tablets (trade name： Madopa) for the treatment of Parkinson’s disease. Methods A total of 118 Parkinson’s disease patients were randomly divided into control group (60 cases) and observation group (58 cases). The control group received only Madopa for treatment， and the observation group received Madopa combined with pramipexole for treatment. Clinical effect was observed in two groups. Evaluation were made on unified Parkinson’s disease rating scale (UPDRS) score and Parkinson’s disease assessment scale (Webster) before and after treatment. Resutls Both groups had improvement of Hoehn-Yahr stage after treatment than before treatment， and the observation group had better improvement than the control group. The differences all had statistical significance (P<0.05). Both groups had lower grade Ⅱ and Ⅲ of UPDRS score than before treatment， and the observation group had lower scores than the control group. The differences all had statistical significance (P<0.05). The observation group had higher total effective rate as 96.6% than 70.0% in the control group， and the difference had statistical significance (P<0.05). The observation group had lower incidence of adverse reactions as 13.8% than 30.0% in the control group， and the difference had statistical significance (P<0.05). Conclusion Combined therapy of pramipexole and Madopa provides better clinical curative effect than Madopa alone， which can effectively improve the clinical symptoms of Parkinson’s disease patients， reduce dyskinesia after meditation and occurrence of drug adverse reactions. So this method is worth promoting and applying., http://www.100md.com(张艳丽 李岩 梁倩 刘闰)
【关键词】 帕金森病；普拉克索；多巴丝肼片
DOI：10.14163/j.cnki.11-5547/r.2017.01.046
Observation on curative effect of pramipexole combined with Madopa for the treatment of Parkinson’s disease ZHANG Yan-li， LI Yan， LIANG Qian， et al. Department of Neurology， Dalian University Affiliated Zhongshan Hospital， Dalian 116000， China
【Abstract】 Objective To observe treatment effect of pramipexole combined with levodopa and benserazide tablets (trade name： Madopa) for the treatment of Parkinson’s disease. Methods A total of 118 Parkinson’s disease patients were randomly divided into control group (60 cases) and observation group (58 cases). The control group received only Madopa for treatment， and the observation group received Madopa combined with pramipexole for treatment. Clinical effect was observed in two groups. Evaluation were made on unified Parkinson’s disease rating scale (UPDRS) score and Parkinson’s disease assessment scale (Webster) before and after treatment. Resutls Both groups had improvement of Hoehn-Yahr stage after treatment than before treatment， and the observation group had better improvement than the control group. The differences all had statistical significance (P<0.05). Both groups had lower grade Ⅱ and Ⅲ of UPDRS score than before treatment， and the observation group had lower scores than the control group. The differences all had statistical significance (P<0.05). The observation group had higher total effective rate as 96.6% than 70.0% in the control group， and the difference had statistical significance (P<0.05). The observation group had lower incidence of adverse reactions as 13.8% than 30.0% in the control group， and the difference had statistical significance (P<0.05). Conclusion Combined therapy of pramipexole and Madopa provides better clinical curative effect than Madopa alone， which can effectively improve the clinical symptoms of Parkinson’s disease patients， reduce dyskinesia after meditation and occurrence of drug adverse reactions. So this method is worth promoting and applying., http://www.100md.com(张艳丽 李岩 梁倩 刘闰)