非酒精性脂肪肝与代谢综合征相关指标变化研究(1)
Study on related indexes changes of non-alcoholic fatty liver disease and metabolic syndrome LI Wei-lan， ZHOU Ying， PAN Chun-mei. South China Agricultural University Hospital， Guangzhou 510642， China
【Abstract】 Objective To explore the correlation between non-alcoholic fatty liver disease (NAFLD) prevalence situation and metabolic syndrome (MS) related indexes changes. Methods Complete medical information of 3071 faulty members was collected to analyze correlation between NAFLD and lipid metabolism disorders， hypertension， hyperglycemia， hypeluricemia level， and NAFLD prevalence situation was studied in different age and gender. Results Among 3071 cases， there were 1022 NAFLD cases， with prevalence rate rate as 33.28%. The incidence of disease rising with age， and male had higher NAFLD prevalence rate than female. The difference had statistical significance (P<0.01). NAFLD group had obviously higher prevalence rate of lipid metabolism disorders， hypertension， hyperglycemia， hypeluricemia level than non NAFLD group， and the difference had statistical significance (P<0.01). NAFLD group had obviously higher body mass index (BMI)， systolic blood pressure (SBP) ， diastolic blood pressure (DBP)， triglyceride (TG)， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， low density lipoprotein cholesterin (LDL-C)， fasting blood-glucose (FBG)， alanine aminotransferase (ALT) and uric acid (UA) level than non NAFLD group， and their difference had statistical significance (P<0.01). NAFLD group had OR value of TG as 1.523， BMI as 1.325， FBG as 1.156 and DBP as 1.429. BMI， FBG， TG and DBP test value were obviously correlated to NAFLD. Conclusion NAFLD occurrence was not only correlated to lipid metabolism disorders， but also closely correlated to age， gender and systemic disease of hyperlipidaemia， hypertension， hyperglycemia and hypeluricemia.
【Key words】 Non-alcoholic fatty liver disease； Metabolic syndrome
隨着人们生活水平的提高以及饮食结构的变化， NAFLD的发病率呈日益增长的趋势， 已成为人们普遍关注的一个公共健康问题[1]。本研究收集了某高校2016年10月3071例教职工的体检完整资料， 调查其NAFLD患病现状， 分析NAFLD与高脂血症、高血压、高血糖、高尿酸等多种代谢紊乱的全身性疾病的变化关系。具体报告如下。
1 资料与方法
1. 1 一般资料 选取2016年10月某高校体检资料完整的3071例教职工作为研究对象， 其中男 1470例， 女1601例， 年龄 22～90岁。纳入标准： ①无饮酒史或酒量不过量；②出现乏力、腹胀、肝区隐痛等症状， 可伴肝、脾肿大；③以ALT为主的血清转氨酶升高， 可伴有谷胺酰转肽酶、 TG等水平增高；④肝脏超声检查符合弥漫性脂肪肝。排除标准：①过量饮酒者(乙醇摄入量>40 g/周)；②慢性病毒性肝炎史、代谢异常和药物等引起的肝病；③全胃肠外营养史；④甲状腺功能亢进、恶性肿瘤病史；⑤自身免疫性肝病和遗传性疾病史。
1. 2 方法 为保证本次研究数据的准确性， 所有体检者腹部彩色多普勒超声检查均由副高以上职称的高年资专科医生操作， 并要求进行空腹测量身高、BMI、 SBP 和 DBP、 BMI、 ALT、 TC、 TG、HDL-C及LDL-C、FBG、尿素、肌酐、 UA、胸片、心电图等临床项目。, 百拇医药(李伟兰 周英 潘春梅)
【Abstract】 Objective To explore the correlation between non-alcoholic fatty liver disease (NAFLD) prevalence situation and metabolic syndrome (MS) related indexes changes. Methods Complete medical information of 3071 faulty members was collected to analyze correlation between NAFLD and lipid metabolism disorders， hypertension， hyperglycemia， hypeluricemia level， and NAFLD prevalence situation was studied in different age and gender. Results Among 3071 cases， there were 1022 NAFLD cases， with prevalence rate rate as 33.28%. The incidence of disease rising with age， and male had higher NAFLD prevalence rate than female. The difference had statistical significance (P<0.01). NAFLD group had obviously higher prevalence rate of lipid metabolism disorders， hypertension， hyperglycemia， hypeluricemia level than non NAFLD group， and the difference had statistical significance (P<0.01). NAFLD group had obviously higher body mass index (BMI)， systolic blood pressure (SBP) ， diastolic blood pressure (DBP)， triglyceride (TG)， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， low density lipoprotein cholesterin (LDL-C)， fasting blood-glucose (FBG)， alanine aminotransferase (ALT) and uric acid (UA) level than non NAFLD group， and their difference had statistical significance (P<0.01). NAFLD group had OR value of TG as 1.523， BMI as 1.325， FBG as 1.156 and DBP as 1.429. BMI， FBG， TG and DBP test value were obviously correlated to NAFLD. Conclusion NAFLD occurrence was not only correlated to lipid metabolism disorders， but also closely correlated to age， gender and systemic disease of hyperlipidaemia， hypertension， hyperglycemia and hypeluricemia.
【Key words】 Non-alcoholic fatty liver disease； Metabolic syndrome
隨着人们生活水平的提高以及饮食结构的变化， NAFLD的发病率呈日益增长的趋势， 已成为人们普遍关注的一个公共健康问题[1]。本研究收集了某高校2016年10月3071例教职工的体检完整资料， 调查其NAFLD患病现状， 分析NAFLD与高脂血症、高血压、高血糖、高尿酸等多种代谢紊乱的全身性疾病的变化关系。具体报告如下。
1 资料与方法
1. 1 一般资料 选取2016年10月某高校体检资料完整的3071例教职工作为研究对象， 其中男 1470例， 女1601例， 年龄 22～90岁。纳入标准： ①无饮酒史或酒量不过量；②出现乏力、腹胀、肝区隐痛等症状， 可伴肝、脾肿大；③以ALT为主的血清转氨酶升高， 可伴有谷胺酰转肽酶、 TG等水平增高；④肝脏超声检查符合弥漫性脂肪肝。排除标准：①过量饮酒者(乙醇摄入量>40 g/周)；②慢性病毒性肝炎史、代谢异常和药物等引起的肝病；③全胃肠外营养史；④甲状腺功能亢进、恶性肿瘤病史；⑤自身免疫性肝病和遗传性疾病史。
1. 2 方法 为保证本次研究数据的准确性， 所有体检者腹部彩色多普勒超声检查均由副高以上职称的高年资专科医生操作， 并要求进行空腹测量身高、BMI、 SBP 和 DBP、 BMI、 ALT、 TC、 TG、HDL-C及LDL-C、FBG、尿素、肌酐、 UA、胸片、心电图等临床项目。, 百拇医药(李伟兰 周英 潘春梅)