老年2型糖尿病患者甲状腺激素水平变化及其临床意义(1)
【摘要】 目的 探究老年2型糖尿病患者甲状腺激素水平变化及其临床意义。方法 100例老年
2型糖尿病患者， 根据病情程度分为轻症组(68例)与重症组(32例)， 并选取同期健康体检50例老年人作为对照组， 对所有研究对象进行胰岛素相关指标(空腹血糖、空腹胰岛素、空腹C肽、糖化血红蛋白)与甲状腺相关指标[甲状腺素(T4)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、反三碘甲状腺原氨酸(rT3)]水平检测并作对比分析。结果 重症组患者空腹血糖、空腹胰岛素、空腹C肽与糖化血红蛋白水平均明显高于轻症组及对照组， 差异具有统计学意义(P<0.05)；轻症组患者空腹血糖(10.3±2.9)mmol/L、空腹C肽(530.6±115.7)mmol/L与糖化血红蛋白水平(7.2±0.9)%均明显高于对照组(5.4±0.7)mmol/L、(380.3±96.7)mmol/L、(5.1±0.4)%， 差异具有统计学意义(P<0.05)；轻症组患者空腹胰岛素水平(40.2±13.6)mmol/L与对照组(38.1±12.3)mmol/L比較差异无统计学意义(P>0.05)。三组研究对象T3、T4、TSH水平比较差异无统计学意义(P>0.05)；重症组患者rT3水平明显高于对照组与轻症组， FT3、FT4明显低于对照组与轻症组， 差异具有统计学意义(P<0.05)；轻症组患者FT3水平明显低于对照组， 差异具有统计学意义(P<0.05)。结论 老年2型糖尿病患者甲状腺激素水平变化情况可以反映出患者病情严重程度， 定期对甲状腺激素水平检测， 可以对病情进行评估， 并为该病的治疗与预后提供有效的指导， 具有重要的价值与意义。
【关键词】 老年2型糖尿病；甲状腺激素水平；变化；临床意义
DOI：10.14163/j.cnki.11-5547/r.2017.30.006
Changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus and its clinical significance BIAN Xin-hua. Department of Clinical Laboratory， Chifeng City Hospital， Chifeng 024000， China
【Abstract】 Objective To investigate the changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus and its clinical significance. Methods A total of 100 elderly patients with type 2 diabetes mellitus were divided by disease severity into mild group (68 cases) and severe group (32 cases)， and concurrent 50 elderly people for physical examination as the control group. Insulin related indicators (fasting blood glucose， fasting insulin， fasting C peptide， glycosylated hemoglobin) and thyroid related index [thyroxine(T4)， three triiodothyronine (T3)， free three triiodothyronine (FT3)， free thyroxine (FT4)， thyroid stimulating hormone (TSH)， reverse - three triiodothyronine (rT3)] levels were detected for comparison analysis. Results The severe group had obviously higher fasting blood glucose， fasting insulin， fasting C peptide and glycosylated hemoglobin levels than mild group and control group， and their difference was statistically significant (P<0.05). The mild group had fasting blood glucose as (10.3±2.9) mmol/L， fasting C peptide as (530.6±115.7) mmol/L and glycosylated hemoglobin as (7.2±0.9)%， which were all obviously higher than (5.4±0.7) mmol/L， (380.3±96.7) mmol/L and (5.1±0.4)% in the control group， and their difference was statistically significant (P<0.05). The mild group had no statistically significant difference in fasting insulin levels as (40.2±13.6)mmol/L， comparing with (38.1±, http://www.100md.com(边新华)
2型糖尿病患者， 根据病情程度分为轻症组(68例)与重症组(32例)， 并选取同期健康体检50例老年人作为对照组， 对所有研究对象进行胰岛素相关指标(空腹血糖、空腹胰岛素、空腹C肽、糖化血红蛋白)与甲状腺相关指标[甲状腺素(T4)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、反三碘甲状腺原氨酸(rT3)]水平检测并作对比分析。结果 重症组患者空腹血糖、空腹胰岛素、空腹C肽与糖化血红蛋白水平均明显高于轻症组及对照组， 差异具有统计学意义(P<0.05)；轻症组患者空腹血糖(10.3±2.9)mmol/L、空腹C肽(530.6±115.7)mmol/L与糖化血红蛋白水平(7.2±0.9)%均明显高于对照组(5.4±0.7)mmol/L、(380.3±96.7)mmol/L、(5.1±0.4)%， 差异具有统计学意义(P<0.05)；轻症组患者空腹胰岛素水平(40.2±13.6)mmol/L与对照组(38.1±12.3)mmol/L比較差异无统计学意义(P>0.05)。三组研究对象T3、T4、TSH水平比较差异无统计学意义(P>0.05)；重症组患者rT3水平明显高于对照组与轻症组， FT3、FT4明显低于对照组与轻症组， 差异具有统计学意义(P<0.05)；轻症组患者FT3水平明显低于对照组， 差异具有统计学意义(P<0.05)。结论 老年2型糖尿病患者甲状腺激素水平变化情况可以反映出患者病情严重程度， 定期对甲状腺激素水平检测， 可以对病情进行评估， 并为该病的治疗与预后提供有效的指导， 具有重要的价值与意义。
【关键词】 老年2型糖尿病；甲状腺激素水平；变化；临床意义
DOI：10.14163/j.cnki.11-5547/r.2017.30.006
Changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus and its clinical significance BIAN Xin-hua. Department of Clinical Laboratory， Chifeng City Hospital， Chifeng 024000， China
【Abstract】 Objective To investigate the changes of thyroid hormone levels in elderly patients with type 2 diabetes mellitus and its clinical significance. Methods A total of 100 elderly patients with type 2 diabetes mellitus were divided by disease severity into mild group (68 cases) and severe group (32 cases)， and concurrent 50 elderly people for physical examination as the control group. Insulin related indicators (fasting blood glucose， fasting insulin， fasting C peptide， glycosylated hemoglobin) and thyroid related index [thyroxine(T4)， three triiodothyronine (T3)， free three triiodothyronine (FT3)， free thyroxine (FT4)， thyroid stimulating hormone (TSH)， reverse - three triiodothyronine (rT3)] levels were detected for comparison analysis. Results The severe group had obviously higher fasting blood glucose， fasting insulin， fasting C peptide and glycosylated hemoglobin levels than mild group and control group， and their difference was statistically significant (P<0.05). The mild group had fasting blood glucose as (10.3±2.9) mmol/L， fasting C peptide as (530.6±115.7) mmol/L and glycosylated hemoglobin as (7.2±0.9)%， which were all obviously higher than (5.4±0.7) mmol/L， (380.3±96.7) mmol/L and (5.1±0.4)% in the control group， and their difference was statistically significant (P<0.05). The mild group had no statistically significant difference in fasting insulin levels as (40.2±13.6)mmol/L， comparing with (38.1±, http://www.100md.com(边新华)