凝血相关指标及血小板对子痫前期的预测价值(1)
【摘要】 目的 觀察凝血相关指标及血小板对子痫前期的预测价值。方法 选择120例子痫前期患者作为研究组， 120例正常妊娠晚期妇女作为对照组。两组均采集空腹静脉血， 比较研究组和对照组凝血指标及血小板参数；比较研究组重度和轻度子痫前期患者凝血指标及血小板参数。结果 研究组患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)短于对照组， 血小板计数(PLT)、血小板压积(PCT)低于对照组， 血浆纤维蛋白原(FIB)、D-二聚体(D-D)、血小板平均体积(MPV)、血小板分布宽度(PDW)高于对照组， 差异有统计学意义(t=9.97、10.44、16.89、24.10、14.98、12.51、9.90、8.53， P<0.05)。
研究组重度子痫前期患者PT、APTT短于轻度子痫前期， PLT、PCT低于轻度子痫前期， FIB、D-D、MPV、PDW高于轻度子痫前期， 差异有统计学意义(t=12.39、11.47、14.38、5.93、13.79、33.87、18.94、4.41， P<0.05)。结论 监测子痫前期妇女凝血指标及血小板状态有利于预测子痫前期的发生、发展， 对临床及时诊断、治疗子痫前期， 并适时终止妊娠有一定指导意义。
【关键词】 凝血指标；血小板；子痫前期
DOI：10.14163/j.cnki.11-5547/r.2018.08.011
Predictive value of coagulation - related indicators and platelet for preeclampsia PENG Zhou-li， XIAO Yu-hui. Department of Obstetrics， Beijing Shunyi Hospital， Beijing 101300， China
【Abstract】 Objective To observe the predictive value of coagulation - related indicators and platelet for preeclampsia. Methods There were 120 preeclampsia patients as research group， and 120 normal late pregnant women as control group. Fasting venous blood was collected in both groups， and coagulation indicators and platelet parameters were compared between study group and control group. The coagulation indicators and platelet parameters of patients with severe and mild preeclampsia were compared in the research group. Results The research group had shorter prothrombin time (PT)， activated partial thromboplastin time (APTT) than the control group， lower platelet count (PLT) and platelet pressure (PCT) than the control group， and higher plasma fibrinogen (FIB)， D-dimer (D-D)， mean platelet volume (MPV)， platelet distribution width (PDW) than the control group. Their difference was statistically significant (t=9.97， 10.44， 16.89， 24.10， 14.98， 12.51， 9.90， 8.53， P<0.05). Severe preeclampsia patients in the research group had shorter PT and APTT than mild preeclampsia patients， lower PLT and PCT than mild preeclampsia patients， and higher FIB， D-D， MPV and PDW than mild preeclampsia patients. Their difference was statistically significant (t=12.39， 11.47， 14.38， 5.93， 13.79， 33.87， 18.94， 4.41， P<0.05). Conclusion Monitoring the blood coagulation index and platelet status of preeclampsia women is helpful for predicting the occurrence and development of preeclampsia， and it has certain guiding significance for timely diagnosis， treatment of preeclampsia and timely termination of pregnancy.
【Key words】 Coagulation indicators； Platelet； Preeclampsia, 百拇医药(彭舟丽 肖玉会)
研究组重度子痫前期患者PT、APTT短于轻度子痫前期， PLT、PCT低于轻度子痫前期， FIB、D-D、MPV、PDW高于轻度子痫前期， 差异有统计学意义(t=12.39、11.47、14.38、5.93、13.79、33.87、18.94、4.41， P<0.05)。结论 监测子痫前期妇女凝血指标及血小板状态有利于预测子痫前期的发生、发展， 对临床及时诊断、治疗子痫前期， 并适时终止妊娠有一定指导意义。
【关键词】 凝血指标；血小板；子痫前期
DOI：10.14163/j.cnki.11-5547/r.2018.08.011
Predictive value of coagulation - related indicators and platelet for preeclampsia PENG Zhou-li， XIAO Yu-hui. Department of Obstetrics， Beijing Shunyi Hospital， Beijing 101300， China
【Abstract】 Objective To observe the predictive value of coagulation - related indicators and platelet for preeclampsia. Methods There were 120 preeclampsia patients as research group， and 120 normal late pregnant women as control group. Fasting venous blood was collected in both groups， and coagulation indicators and platelet parameters were compared between study group and control group. The coagulation indicators and platelet parameters of patients with severe and mild preeclampsia were compared in the research group. Results The research group had shorter prothrombin time (PT)， activated partial thromboplastin time (APTT) than the control group， lower platelet count (PLT) and platelet pressure (PCT) than the control group， and higher plasma fibrinogen (FIB)， D-dimer (D-D)， mean platelet volume (MPV)， platelet distribution width (PDW) than the control group. Their difference was statistically significant (t=9.97， 10.44， 16.89， 24.10， 14.98， 12.51， 9.90， 8.53， P<0.05). Severe preeclampsia patients in the research group had shorter PT and APTT than mild preeclampsia patients， lower PLT and PCT than mild preeclampsia patients， and higher FIB， D-D， MPV and PDW than mild preeclampsia patients. Their difference was statistically significant (t=12.39， 11.47， 14.38， 5.93， 13.79， 33.87， 18.94， 4.41， P<0.05). Conclusion Monitoring the blood coagulation index and platelet status of preeclampsia women is helpful for predicting the occurrence and development of preeclampsia， and it has certain guiding significance for timely diagnosis， treatment of preeclampsia and timely termination of pregnancy.
【Key words】 Coagulation indicators； Platelet； Preeclampsia, 百拇医药(彭舟丽 肖玉会)