炙甘草汤加减治疗冠心病心律失常的临床价值分析(1)
【摘要】 目的 探討炙甘草汤加减治疗冠心病心律失常的临床价值。方法 180例冠心病心律失常患者， 采用随机数字表法分为对照组与观察组， 每组90例。对照组实施胺碘酮治疗， 观察组在对照组基础上联用炙甘草汤加减治疗。观察比较两组疗效、心悸症状消失时间、气短症状消失时间、乏力症状消失时间、不良反应发生情况及治疗前后中医症状积分、心功能情况。结果 治疗后， 观察组总有效率95.56%高于对照组的66.67%， 差异具有统计学意义(P<0.05)。观察组心悸症状消失时间(6.12± 1.25)d、气短消失时间(6.11±1.21)d、乏力消失时间(5.12±0.53)d均短于对照组的(8.47±2.14)、(8.42± 2.03)、(7.23±1.56)d， 差异具有统计学意义(P<0.05)。治疗后， 两组中医症状积分、左室舒张末期内径、左室收缩末期内径、左室射血分数均优于治疗前， 且观察组上述指标优于对照组， 差异具有统计学意义(P<0.05);两组不良反应发生率比较， 差异无统计学意义(P>0.05)。结论 胺碘酮联合炙甘草汤加减治疗冠心病心律失常的疗效优于单用胺碘酮的疗效， 且心悸、气短、乏力症状的消失时间较短， 对于心功能改善情况较好， 值得临床推广应用。
【关键词】 炙甘草汤加减;冠心病心律失常;临床价值
【Abstract】 Objective To discuss the clinical value of addition and subtraction of Zhigancao decoction in treating arrhythmia of coronary heart disease. Methods A total of 180 patients with arrhythmia of coronary heart disease were divided by random number table method into control group and observation group， with 90 cases in each group. The control group was treated with amiodarone， and the observation group was treated with addition and subtraction of Zhigancao decoction on the basis of the control group. Observation and comparison were made on efficacy， disappearance time of palpitation symptoms， shortness of breath symptoms， fatigue symptoms， occurrence of adverse reactions， TCM symptom scores and cardiac function before and after treatment in two groups. Results After treatment， the observation group had higher total effective rate as 95.56% than 66.67% in the control group， and the difference was statistically significant (P<0.05). The observation group had shorter disappearance time of palpitation symptoms as (6.12±1.25) d， disappearance time of shortness of breath symptoms as (6.11±1.21) d， disappearance time of fatigue symptoms as (5.12±0.53) d than (8.47±2.14)， (8.42±2.03) and (7.23±1.56) d in the control group. Their difference was statistically significant (P<0.05). After treatment， both groups had better TCM symptom score， left ventricular end diastolic diameter， left ventricular end systolic diameter and left ventricular ejection fraction than those before treatment， and the observation group had better above indicators than the control group. Their difference was statistically significant (P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions (P>0.05). Conclusion The effect of amiodarone combined with Zhigancao decoction in treating arrhythmia of coronary heart disease is better than that of amiodarone alone， and the disappearance time of palpitation， shortness of breath and fatigue symptoms is shorter. It is better for improving cardiac function and worthy of clinical application., 百拇医药(曾文新)
【关键词】 炙甘草汤加减;冠心病心律失常;临床价值
【Abstract】 Objective To discuss the clinical value of addition and subtraction of Zhigancao decoction in treating arrhythmia of coronary heart disease. Methods A total of 180 patients with arrhythmia of coronary heart disease were divided by random number table method into control group and observation group， with 90 cases in each group. The control group was treated with amiodarone， and the observation group was treated with addition and subtraction of Zhigancao decoction on the basis of the control group. Observation and comparison were made on efficacy， disappearance time of palpitation symptoms， shortness of breath symptoms， fatigue symptoms， occurrence of adverse reactions， TCM symptom scores and cardiac function before and after treatment in two groups. Results After treatment， the observation group had higher total effective rate as 95.56% than 66.67% in the control group， and the difference was statistically significant (P<0.05). The observation group had shorter disappearance time of palpitation symptoms as (6.12±1.25) d， disappearance time of shortness of breath symptoms as (6.11±1.21) d， disappearance time of fatigue symptoms as (5.12±0.53) d than (8.47±2.14)， (8.42±2.03) and (7.23±1.56) d in the control group. Their difference was statistically significant (P<0.05). After treatment， both groups had better TCM symptom score， left ventricular end diastolic diameter， left ventricular end systolic diameter and left ventricular ejection fraction than those before treatment， and the observation group had better above indicators than the control group. Their difference was statistically significant (P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions (P>0.05). Conclusion The effect of amiodarone combined with Zhigancao decoction in treating arrhythmia of coronary heart disease is better than that of amiodarone alone， and the disappearance time of palpitation， shortness of breath and fatigue symptoms is shorter. It is better for improving cardiac function and worthy of clinical application., 百拇医药(曾文新)