葫芦素B抑制STAT3/Bcl-2表达诱导非小细胞肺癌H1975细胞凋亡(4)
[10] Zhang ZR, Gao MX, Yang K. Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways. Exp Ther Med, 2017, 14(1):805-812.
[11] Silva IT, Geller FC, Persich L, et al. Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549. Invest New Drugs, 2016, 34(2):139-148.
[12] Zhang M, Bian ZG, Zhang Y, et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep, 2014, 10(6):2905-2911.
[13] Wiart C. The definition and significance of Cucurbitacin B a STAT3 inhibitors. Cancer Lett, 2013, 328(1):188.
[14] Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene, 2002, 21(13):2000-2008.
[15] Malladi S, Challa-Malladi M, Fearnhead HO, et al. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J, 2009, 28(13):1916-1925.
[16] Inoue S, Browne G, Melino G, et al. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ, 2009, 16(7):1053-1061.
[收稿日期:2020-01-07], 百拇医药(何臣 王菊辉 丘韶校 徐羽中 李元广)
[11] Silva IT, Geller FC, Persich L, et al. Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549. Invest New Drugs, 2016, 34(2):139-148.
[12] Zhang M, Bian ZG, Zhang Y, et al. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells. Mol Med Rep, 2014, 10(6):2905-2911.
[13] Wiart C. The definition and significance of Cucurbitacin B a STAT3 inhibitors. Cancer Lett, 2013, 328(1):188.
[14] Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene, 2002, 21(13):2000-2008.
[15] Malladi S, Challa-Malladi M, Fearnhead HO, et al. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J, 2009, 28(13):1916-1925.
[16] Inoue S, Browne G, Melino G, et al. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ, 2009, 16(7):1053-1061.
[收稿日期:2020-01-07], 百拇医药(何臣 王菊辉 丘韶校 徐羽中 李元广)