四联疗法与传统三联疗法对Hp感染阳性慢性胃炎患者胃肠功能及症状的影响(1)
【摘要】 目的 探究四联疗法与传统三联疗法对幽门螺杆菌(Hp)感染阳性慢性胃炎患者胃肠功能及症状的影响。方法 200例Hp感染阳性慢性胃炎患者， 根据治疗方式的不同分为对照组和观察组， 各100例。对照组采用传统三联疗法(雷贝拉唑钠、阿莫西林、克拉霉素)， 观察组采用四联疗法(胶体果胶铋、雷贝拉唑钠、阿莫西林、克拉霉素)。对比两组患者治疗前后临床症状积分及治疗效果、Hp根除率和不良反应发生情况。结果 治疗后， 观察组腹痛、腹胀和反酸嗳气积分分别为(0.35±0.11)、(0.28±0.10)、(0.27±0.14)分均低于对照组的(1.10±0.32)、(1.22±0.27)、(1.12±0.22)分， 差异具有统计学意义(P<0.05)。观察组治疗总有效率89.00%和Hp根除率88.00%均高于对照组76.00%、74.00%， 差异具有统计学意义(P<0.05)。兩组不良反应发生率对比差异无统计学意义(P>0.05)。结论 在Hp感染阳性慢性胃炎患者治疗中， 传统三联疗法和四联疗法均有较好的安全性， 但四联疗法疗效更为显著， 对临床症状改善情况更好， Hp根除率更高， 值得应用。
【关键词】 慢性胃炎;幽门螺杆菌感染;胶体果胶铋;雷贝拉唑钠;阿莫西林;克拉霉素;胃肠功能
DOI：10.14163/j.cnki.11-5547/r.2020.30.051
Effects of quadruple therapy and traditional triple therapy on gastrointestinal function and symptoms in chronic gastritis patients with positive Hp infection CHENG Yuan-xing. Shanxian Central Hospital， Heze 274300， China
【Abstract】 Objective To investigate the effect of quadruple therapy and traditional triple therapy on gastrointestinal function and symptoms in chronic gastritis patients with positive Helicobacter pylori (Hp) infection. Methods A total of 200 chronic gastritis patients with positive Hp infection were divided into control group and observation group according to different treatment methods， with 100 cases in each group. The control group received traditional triple therapy (rabeprazole sodium， amoxicillin， clarithromycin)， and the observation group received quadruple therapy (colloidal bismuth pectin， rabeprazole sodium， amoxicillin， clarithromycin). The clinical symptom integral before and after treatment， therapeutic effect， Hp eradication rate and occurrence of adverse reactions were compared between the two groups. Results After treatment， the abdominal pain， bloating and acid reflux integral of the observation group were (0.35±0.11)， (0.28±0.10) and (0.27±0.14) points， which were lower than (1.10±0.32)， (1.22±0.27) and (1.12±0.22) points of the control group， and the difference was statistically significant (P<0.05). The total effective rate of treatment 89.00% and Hp eradication rate 88.00% of the observation group were higher than 76.00% and 74.00% of the control group， and the difference was statistically significant (P<0.05). There was no statistically significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of chronic gastritis patients with positive Hp infection， the traditional triple therapy and quadruple therapy have good safety， but the quadruple therapy has more significant effect， better improvement of clinical symptoms and higher Hp eradication rate， which is worthy of application., 百拇医药(程元星)
【关键词】 慢性胃炎;幽门螺杆菌感染;胶体果胶铋;雷贝拉唑钠;阿莫西林;克拉霉素;胃肠功能
DOI：10.14163/j.cnki.11-5547/r.2020.30.051
Effects of quadruple therapy and traditional triple therapy on gastrointestinal function and symptoms in chronic gastritis patients with positive Hp infection CHENG Yuan-xing. Shanxian Central Hospital， Heze 274300， China
【Abstract】 Objective To investigate the effect of quadruple therapy and traditional triple therapy on gastrointestinal function and symptoms in chronic gastritis patients with positive Helicobacter pylori (Hp) infection. Methods A total of 200 chronic gastritis patients with positive Hp infection were divided into control group and observation group according to different treatment methods， with 100 cases in each group. The control group received traditional triple therapy (rabeprazole sodium， amoxicillin， clarithromycin)， and the observation group received quadruple therapy (colloidal bismuth pectin， rabeprazole sodium， amoxicillin， clarithromycin). The clinical symptom integral before and after treatment， therapeutic effect， Hp eradication rate and occurrence of adverse reactions were compared between the two groups. Results After treatment， the abdominal pain， bloating and acid reflux integral of the observation group were (0.35±0.11)， (0.28±0.10) and (0.27±0.14) points， which were lower than (1.10±0.32)， (1.22±0.27) and (1.12±0.22) points of the control group， and the difference was statistically significant (P<0.05). The total effective rate of treatment 89.00% and Hp eradication rate 88.00% of the observation group were higher than 76.00% and 74.00% of the control group， and the difference was statistically significant (P<0.05). There was no statistically significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of chronic gastritis patients with positive Hp infection， the traditional triple therapy and quadruple therapy have good safety， but the quadruple therapy has more significant effect， better improvement of clinical symptoms and higher Hp eradication rate， which is worthy of application., 百拇医药(程元星)