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Hcy、MPV、hs—CRP及FIB对急性脑梗死诊断的价值(1)
http://www.100md.com 2018年9月1日 《检验医学》 20189
     摘要:目的研究Hcy同型半胱氨酸、hs-CRP高敏C反应蛋白、FIB纤维蛋白原以及MPV平均血小板体积检测对急性脑梗死患者的临床诊断价值。方法选取150例急性脑梗死患者作为研究对象,并依据神经缺损程度将其分为轻度损伤组、中度损伤组与重度损伤组,选取同时期100例健康体检者作为对照组,将急性脑梗死的损伤组同正常对照组进行各项指标变化情况进行对比分析。结果急性脑梗死患者的Hcy、MPV、hs-CRP及FIB数据明显高于正常对照组的相应数据,P<005,有统计学意义。将轻度、中度、重度三个损伤组的Hcy、MPV、hs-CRP及FIB检验数据进行对比分析,发现数据间差异性较大,P<005,有统计学意义,且随着损伤程度的加重,Hcy、MPV、hs-CRP及FIB数据也越高。结论对于急性脑梗死患者而言,Hcy、MPV、hs-CRP及FIB的检测对其病情的判断和预后有着较好的辅助作用。

    关键词:急性脑梗死;高敏C反应蛋白;平均血小板体积;同型半胱氨酸;纤维蛋白原

    文章编号:1673-8640(2018)-0059-02

    中图分类号:R743.33

    文献标志码:B

    Abstract:

    ObjectiveTo study the clinical diagnostic value of Hcy homocysteine, hs-CRP high-sensitivity C-reactive protein, FIB fibrinogen and MPV mean platelet volume in patients with acute cerebral infarction. Method 150 patients with acute cerebral infarction were selected as the research subjects. According to the degree of nerve defect, they were divided into mild injury group, moderate injury group and severe injury group. 100 healthy subjects in the same period were selected as the control group. The injury group of cerebral infarction was compared with the normal control group for comparison. Result The data of Hcy, MPV, hs-CRP and FIB in patients with acute cerebral infarction were significantly higher than those in the normal control group, P<005, which was statistically significant. The Hcy, MPV, hs-CRP and FIB test data of the mild, moderate and severe injury groups were compared and analyzed. It was found that the data were significantly different, P<005, statistically significant, and with the degree of damage The increase, the higher the Hcy, MPV, hs-CRP and FIB data. Conclusion For patients with acute cerebral infarction, the detection of Hcy, MPV, hs-CRP and FIB has a good auxiliary effect on the judgment and prognosis of the disease.

    Key words:acute cerebral infarction; high-sensitivity C-reactive protein; mean platelet volume; homocysteine; fibrinogen

    目前,急性腦梗死是一种在临床中较为常见的神经内科疾病,对此类患者的及时、早期、有效的治疗能够极大程度地降低患者的病死率,从而为患者的生命健康提供保障[1]。动脉粥样硬化是诱发急性脑梗死的一种常见病因,据相关资料显示,血浆同型半管氨酸是造成且加速动脉粥样硬化的一项重要独立危险因素,对于处于脑梗死急性期的患者而言,Hcy、MPV、hs-CRP及FIB的相关检测数据均会出现异常变化[2]。为了探讨Hcy、MPV、hs-CRP及FIB检测对急性脑梗死患者的临床诊断价值,本文选取2017年3月到2018年7月在我院接受治疗的150例急性脑梗死患者,及同时期100例健康体检者作为研究对象进行分析,结果报告如下:

    资料与方法

    一、一般资料资料来源于2017年3月到2018年7月在我院接受治疗的150例急性脑梗死患者,及同时期在我院进行体检的100例健康体检者。将上述人员作为研究对象,依据神经功能的损伤程度,将急性脑梗死患者组再细分为轻度损伤组、中度损伤组、重度损伤组,每组患者人数人别为40例、71例、39例。健康体检患者作为对照组。其中急性脑梗死患者组中,男女比例为79:71,年龄在66~81岁,年龄范围(70.16±4.28)岁,健康对照组男女比例为64:46,年龄在61~78岁,年龄范围(69.42±3.55)岁.两组患者在性别、年龄、居住环境等一般资料上不存在显著差异(P>005),有可比性。, http://www.100md.com(符丽艳 李杭娟)
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