43例新生儿先天性感染TORCH的临床分析(1)
【摘要】目的对先天性感染TORCH的新生儿进行临床分析。方法用ELASA法检测血清中TORCH(弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒)IgM。结果2004年1月至2008年6月本院新生儿重症监护室共收治1352例,其中43例为TORCH感染,巨细胞病毒感染率为48.8%;风疹病毒感染占32.6%;单纯疱疹病毒感染占18.6%,未发现有弓形体感染者。其临床特点主要为听力异常、高胆红素血症和肝功能异常、神经系统损伤、心肌损伤、血小板减少、先天性心脏病等。结论新生儿TORCH感染可造成多器官损伤,危害性大,对可疑患儿进行筛查是必要的,预防应从母亲怀孕期开始【关键词】
TORCH感染;先天性;新生儿
Clinical analysis of 43 congenital TORCH infections in newborns
SUN Xi-feng,Sun Xiao-wei,Chang Li-jun,et al.Clinical Laboratory,Weifang People’s Hospital,Weifang 261041,China
【Abstract】ObjectiveTo search for the early clinical manifestations as evidences for prevention and treatment TORCH infections in newborns as early as possible.MethodsELASA was performed to screen specific anti-TORCH(Toxoplasma gondlii,Cystomegalovirus,Rubella virus,Herpes simplex virus)Ig-M antibodies.RESULTS Totally 1352 in-patients who were treated in Neonatal Intemaive Care Unit(NICU)of our hospital from January 2007 to June 2008 were retrospectively studied,43 of them had TORCH infections.Cytomegalovirus,rubella and herpes simples virus infections accounted for 48.8%,32.6% and 18.6%,respectively.None of them had toxoplasma infection.The main clinical manifestations of them were hearing impairment,hyperbilirubinemias and liver dysfuntion,impairment of neurologic system,myocardial impairment,thrombocytopenia,and congenital heart disease.ConclusionTORCH infections can cause multiorgan lesions.Rubella vaccine inoculation,serological screening during pregnancy and early period of newborn,intervention and treatment in the early period are most important. ......
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