产妇DIC中凝血与纤溶系统水平临床分析(1)
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【摘要】 目的 探讨产妇弥漫肉性血管内凝血(DIC)时凝血与纤溶系统水平检测并分析。方法 本院2004年1月至2009年1月产科DIC52例为DIC组,同期与本科健康体检的门诊患者60例为对照组,检测内容:凝血酶原时间( PT) 、活化的部分凝血活酶时间(APTT) ; D2二聚体(D-D) 、纤维蛋白/纤维蛋白原降解产物( FDP) 、3 P试验,进行比较并观察各指标间的相关性。结果 DIC组与对照组进行观察检测内容比较P<0.05,有显著差异性。结论 产妇患者出现明显的凝血功能指标如D-D、PT、FDPAPTT等明显异常时,应特别警惕D IC的可能。如存在D IC的诱发因素和凝血、纤溶异常但尚未达到D IC的确诊标准,可能正处于D IC的前状态,应引起临床高度的重视,笔者的观察显示,联合D-D,FDP和APTT检测是早期诊断DIC的最好策略。
【关键词】 产妇;DIC;凝血与纤溶系统水平检测;临床分析
Clincal analysis coagulation and fibrinolytic system-level testing of parturient with DIC
XU Xiu-hua.
gynecology and obstetrics departmentthe first People’s Hospital
Henan,Shanqiu 476100,China
【Abstract】 Objective To investigate the coagulation and fibrinolytic system level in parturient with DIC. Methods The hospital January 2004 to January 2009 obstetrics DIC52 cases of DIC group,compared with the physical examination of the outpatient department from 60 cases as control group,test content: prothrombin time (PT),activated partial thromboplastin live enzymes Time (APTT); D2 dimer (DD),fibrin / fibrinogen degradation products (FDP),3 P test,compare and observe the correlation between each index. Results DIC group and the control group compared to observe the contents of P<0.05,significant difference. Conclusion Coagulation function in patients with apparent indicators such as the DD,PT,FDPAPTT the obvious exception should be particularly vigilant D IC possible. D IC such as the existence of predisposing factors and blood coagulation and fibrinolysis abnormalities,but the diagnosis has not yet reached D IC standards,may be the first state in the D IC,should arouse a high degree of clinical importance,our observations show that the joint DD,FDP and APTT test is the best strategy for early diagnosis of DIC.
【Key words】 Parturient DIC;Coagulation and fibrinolytic system-level testing;Clinical analysis
弥漫性血管内凝血(disseminatedinartvascularcoagulatinn,DIC) 是在某些致病因素的作用下,全身小血管内广泛的微血栓形成以及继发性纤溶受抑的一种以凝血一抗凝血与纤
溶一抗纤溶失衡为病理特征的临床血栓一出血综合征[1]。产妇DIC是在合并产科疾病的基础上并发微血栓形成,从而发生凝血功能障碍,继之并发多功能衰竭。是孕产妇危重症之一,发病急骤,病情复杂而凶险,导致严重的出血,母婴死亡率极高。为了提高对本病的诊断的指导,笔者对产妇DIC凝血与纤溶系统水平此进行了深入的研究 ......
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