血清VEGF的表达与肌营养不良症的关系(1)
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【摘要】 目的 检测肌营养不良症患者的血清血管生长因子(VEGF)水平,鉴定其是否与肌营养不良症的疾病发展有关。方法 对46例肌营养不良患者,其中32例Duchenne 肌营养不良症 (DMD)、9例Becker肌营养不良症 (BMD)、5例强直性肌营养不良症(DM)患者的血清VEGF水平进行检测。15例健康人和8例疾病患者为对照组。结果 DMD患者血清VEGF为(274.7 ± 2.52)pg/ml,BMD患者的为(358.8 ± 9.64) pg/ml,DM患者为(165.0 ± 6.34) pg/ml,而健康对照组为(1 48.3 ± 2.91) pg/ml,疾病对照组为(153.7 ± 5.42) pg/ml。与DM组和对照组相比,BMD的VEGF水平显著提高。而DMD组中卧床的患者相对于坐轮椅的DMD、DM组和对照组则VEGF水平显著升高。结论 VEGF可以反映肌肉组织低氧和/或缺血状况,并且与DMD和BMD患者的疾病发展过程有关。
【关键词】 Becker肌营养不良症; Duchenne 肌营养不良症; 血管生长因子
The relationship between serum levels of vascular endothelial growth factor andmuscular dystrophy development
WANG Wen-feng,PENG Jia- peng,MA Pei-jiong,et al.
Chao-Nan Hospital of Shantou,Shantou Guangdong 515144,China
【Abstract】 Objective To detect serum levels of vascular endothelial growth factor (VEGF) in patients with muscular dystrophy and further to examine whether VEGF is associated with muscular dystrophy development. Methods We measured serum levels of VEGF in 32 patients with DMD,9 with Becker muscular dystrophy (BMD),5 with myotonic dystrophy (DM),as well as in 15 healthy and eight disease controls. Results The serum level of VEGF in the DMD patients was (274.7 ± 2.52)pg/ml,while it was(358.8 ± 9.64) pg/ml in the BMD patients,(165.0 ± 6.34)pg/ml in the DM patients,(1 48.3 ± 2.91) pg/ml in the healthy controls,and (153.7 ± 5.42) pg/mlin the disease controls. The level of VEGF in BMD was significantly elevated,as compared with DM and control groups. Further,the level of VEGF in the bedridden sub-group of DMD patients was significantly elevated as compared with chair-bound DMD,DM,and control groups. Conclusion We concluded that VEGF may reflect hypoxic and/or ischemic conditions in muscle tissue,and have a relationship with the process of disease progression in DMD and BMD patients.
【Key words】 Becker muscular dystrophy (BMD); Duchenne muscular dystrophy (DMD); Vascular endothelial growth factor (VEGF)
肌营养不良症患者存在无症状纤维蛋白溶解凝聚异常[1]。已有研究报道在DMD患者早期病程中即存在内皮细胞异常肿胀、基底膜增厚、血小板粘附聚集、小血管血栓形成。这些结果表明肌营养不良症的患者肌肉组织因微循环异常容易发生缺血缺氧 ......
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