高血压患者脉搏波速度的变化及琥珀酸美托乐尔缓释片干预的影响(1)
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【摘要】 目的 探讨琥珀酸美托乐尔缓释片对高血压患者脉搏波速度的影响。方法 28例首次确诊的高血压患者与28例正常对照组对比分析血压、血糖、血脂和脉搏波速度,琥珀酸美托乐尔缓释片治疗12周后重复测量上述指标,前后对比分析血压和脉搏波速度的变化。结果 高血压患者收缩压(156.3±8.6)mm Hg比(112.6±11.9 mm Hg、舒张压(103.6±6.7)mm Hg比(68.2±8.9)mm Hg和脉搏波速度(1971.3±187.4)cm/s比(1187.2±198.5)cm/s显著高于正常对照组(P<0.05)。琥珀酸美托乐尔缓释片治疗12周后,患者心率(85.2±4.7)比(64.5±6.3)收缩压(156.3±8.6)mm Hg比(121.9±7.9)mm Hg、舒张压(103.6±6.7)mm Hg比(76.3±5.1)mm Hg和脉搏波速度(1971.3±187.4)cm/s 比(1236.5±186.3)cm/s)显著下降(P<0.05)。 结论 琥珀酸美托乐尔缓释片可以降低高血压患者的脉搏波速度,改善动脉顺应性。
【关键词】高血压;脉搏波速度; 琥珀酸美托乐尔缓释片
Effects of metoprolol succinate sustained release tablets on pulse wave velocity in patients with essential hypertension
LIU Heng liang,LIU Yang,GENG Guo ying,et al.Department of cardiology,Zhengzhou People’s hospital,Zhengzhou 450002,China
【Abstract】 Objective To evaluate the effects of metoprolol succinate sustained release tablets on Brachial ankle pulse wave velocity(baPWV)in patients with essential hypertension.Methods The levels of serum blood lipid and blood glucose,blood pressure,heart rate and baPWV were measured respectively in twenty eight patients with essential hypertension andtwenty eight healthy persons with normal blood pressure.After twelve weeks treated with metoprolol succinate sustained release tablets,The blood pressure and baPWV were measured again and were studied in patients with essential hypertension.Results The systolic blood pressure(156.3±8.6)mm Hg vs(112.6±11.9)mm Hg,diastolic blood pressure(103.6±6.7)mm Hg vs(68.2±8.9)mm Hg and baPWV(1971.3±187.4)cm/s vs(1187.2±198.5)cm/s in patients with essential hypertension were higher than that of healthy persons with normal blood pressure significantly(P<0.05),The heart rate(85.2±4.7)vs(64.5±6.3) beat/min,systolic blood pressure(156.3±8.6)mm Hg vs(121.9±7.9)mm Hg,diastolic blood pressure(103.6±6.7)mm Hg vs(76.3±5.1)mm Hg and baPWV(1971.3±187.4)cm/s vs(1236.5±186.3)cm/s were decreased significantly in patients with essential hypertension(P<0.05)after treated with metoprolol succinate sustained release tablets.Conclusion Metoprolol succinate sustained release tablets treated in patients with essential hypertension can decreased pulse wave velocity,impore elasticity of large arterise and increase the distensibility of aorta ......
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