血脂\血糖与脑血流联合分析在惊恐障碍中的应用(1)
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【摘要】 目的 探讨惊恐障碍患者的血脂、空腹及餐后2 h血糖水平、脑血流的变化。方法 将首诊于综合性医院急诊科惊恐障碍患者60例分成有自杀意念和没有自杀意念两组,并和30名正常对照进行上述四组指标比较。结果 单因素方差分析显示惊恐障碍伴自杀意念者血浆总胆固醇(TCh)、低密度脂蛋白胆固醇(LDL)明显低于惊恐障碍不伴自杀意念者及正常对照组(P<0.05),前者餐后2 h血糖(2 hBS)明显高于后者及正常对照组(P<0.05)。经颅多普勒(TCD)检查发现:惊恐障碍伴自杀意念者左大脑中动脉(LMCA)平均峰、左大脑前动脉(LACA)平均峰、右大脑中动脉(RMCA)平均峰明显低于惊恐障碍不伴自杀意念者和健康对照(P<0.05)。将上述检查结果中有统计学意义的TCh、LDL、餐后2 hBS、LMCA平均峰、LACA平均峰、RMCA平均峰进行多分类Logistic回归分析,结果显示LDL、LMCA平均峰、RMCA平均峰惊恐障碍伴自杀意念者明显低于惊恐障碍不伴自杀意念者(P<0.05),TCh、餐后2 hBS、LACA平均峰两组无统计学意义(P>0.05)。结论 低LDL、脑血流量改变可能是惊恐障碍的神经生物学指标之一。
【关键词】惊恐障碍;血脂;空腹及餐后2 h血糖;脑血流;急诊科
Clinical applicatoin of combined detection of serum lipid、blood sugar and cerebral blood flow in panic disorder
ZHAO Yi,SUN mei hua.Department of Emergency,the Centrol People Hospital of Tengzhou,Tengzhou 277500,China
【Abstract】 Objective To investigate the level of serum lipid,fasting and two hour’s post prandial blood sugar and cerebral blood flow in panic disorder patients.Methods 60 panic disorder(PD)patients of emergency department divided into two groups according to the suicide idea,and compared with 30 controls.Results The study found that the panic disorder with suicide idea had significant lower level of total cholesterol
(TCh),(P<0.05).low density lipoprotein compared with no suicide idea and control,(P<0.05)2 hBS higher in panic disorder with suicide idea(P<0.05).The mean cerebral blood peak flow velocity in the left and right middle cerebral artery and left anterior cerebral artery were lower than those of with patients without suicide idea and controls(P<0.05).Correlation factors were analyzed by regression in PD group.The patients with suicide idea were significant lower in low density lipoprotein,left and right middle cerebral artery than those of without suicide idea,while the concentrations of TC,2Hbs and left anterior cerebral had no significant difference between them.Conclusion The change of LDL and cerebral blood flow may be the neurobiology indicators.
【Key words】Panic disorder; Serum lipid; Fasting and two hour post prandial blood sugar; Cerebral blood flow; Emergency department
惊恐障碍(Panic Disorder,PD)是一种急性焦虑障碍,临床以反复惊恐发作为特征,呈突然感到濒临灾难性结局的害怕和恐惧,伴显著的植物神经功能亢进 ......
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