育龄期多囊卵巢综合征患者的糖代谢异常和胰岛素抵抗(1)
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【摘要】 目的 探讨育龄期多囊卵巢综合征(PCOS)患者的糖代谢异常和胰岛素抵抗。方法 选择育龄期PCOS患者168例,分为肥胖PCOS组78例和非肥胖PCOS组90例,正常对照组100例,对比临床表现及检测内分泌激素、空腹血糖、空腹胰岛素、服糖后2 h血糖及2 h胰岛素。结果 育龄期PCOS患者的月经周期、多毛、痤疮、B超提示卵巢增大、卵巢多囊性改变、有不孕史与对照组比较,差异均有显著性(P<0.05),育龄期PCOS组的血清LH、T与对照组比较,差异有显著性(P<0.05)。育龄期肥胖PCOS组的空腹血糖、服糖后2 h血糖、空腹胰岛素、服糖后2 h胰岛素与对照组比较,差异均有显著性(P<0.05)。结论 早期出现月经稀发、BMI升高的患者是否存在PCOS,值得重视。育龄期PCOS患者尤其肥胖型要高度重视糖代谢异常及胰岛素抵抗,以决定是否采取干预措施,避免出现远期并发症而对PCOS患者造成健康威胁。
【关键词】育龄期;多囊卵巢综合征;糖代谢;胰岛素
The correlation between glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome
LIU Hui fen,QIU Hua juan,CHEN Mei ying,et al.Department of Obstetrics and Gynecology,Huizhou Municipal Central Hospital of Guangdong Province,Huizhou 516001,China
【Abstract】 Objective To investigate glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome(PCOS).Methods Seventy eight cases of obese women with PCOS,ninety cases of non obese women with PCOS and one hundred cases of control group were reviewed regarding clinical features,endocrinal hormone,fasting glucose,fasting insulin,2 h postprandial glucose and 2 h postprandial insulin.Results The menstrual cycle,Hirsutism,acne,ultrasonography suggested ovarian increase,polycystic ovary change and infertility of adult women with PCOS were significantly different compared with the control group(P<0.05).And the fasting glucose,2 h postprandial glucose,fasting insulin,2 h postprandial insulin of the obese group were also significantly higher compared with the control group(P<0.05).Conclusion Attention would be paid to patients with early oligomenorrhea and high BMI for PCOS diagnosis.Adult women with PCOS especially the obese should check abnormal glucose metabolism and insulin resistance to determine whether actions should be taken to avoid the menace of long term complication.
【Key words】Adult women; Polycystic ovary syndrome; Carbohydrate metabolism; Insulin resistance
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄妇女最常见的生殖内分泌、代谢紊乱等诸多因素的终身性疾病,是以雄激素过多及长期无排卵为特征,是育龄妇女常见的一种极为复杂的内分泌及糖代谢异常所致的病理状态,发病率为5%~10%[1] ......
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