血液透析肾性贫血患者蔗糖铁治疗后骨髓象及铁代谢的临床观察(1)
 |
| 第1页 |
参见附件(2294KB，3页)。
【摘要】 目的 观察应用蔗糖铁治疗维持性血液透析肾性贫血患者的骨髓象在治疗前后的变化,探讨蔗糖铁对肾性贫血患者骨髓和铁代谢的影响。方法 对22例维持性血液透析肾性贫血患者每周2次,每次100 mg蔗糖铁于血液透析时由动脉端输入,总量1000 mg。全部病例都合并使用红细胞生成素(EPO)治疗,剂量为120~150 U/(kg•周),皮下或静脉应用,观察治疗前后贫血纠正情况,骨髓红系各指标,铁代谢指标的变化,探讨蔗糖铁治疗的效果。结果 22例患者治疗5周后血色素(Hb)明显上升(P<0.01),红系骨髓象增生活跃程度比治疗前明显增强(P<0.01),且增幅高于红系血象各指标,血清铁、铁蛋白、转铁蛋白饱和度均升高(P<0.01)。结论 静脉注射蔗糖铁能保证EPO的铁需求,增强疗效。
【关键词】蔗糖铁;肾性贫血;骨髓象;铁代谢
The effet of iron sucrose injection for renal anemian on bone and iron metabolism
YUAN Hong ling,ZHOU Xiao ping,WEN jia,et al.Department of Nephrology,Yunnan Provincial The First People"s Hospital,Kunming 650032,China
【Abstract】 Objective To observe the change of the bone marrow manifestation after the treatment of
DOI:10.3760/cma.j.issn 1673 8799.2010.05.40
作者单位:650032昆明,昆明医学院附属昆华医院/云南省第一人民医院肾脏内科
renal anaemia with Iron Sucrose Injection.And approach the influence of Iron Sucrose Injection to renal anaemia patients’ bone marrow and iron metabolism.Methods 22 cases of renal anaemia patients were treated with Iron Sucrose Injection.Intravenously guttae Iron Sucrose Injection from the artery side during hemodialysis(100 mg each time,twice every week,and the volume dose was 1000 mg).All the cases were injected erythropoietin(EPO)with the dose of 120 150U.kg 1.week 1.Then observe the change of anaemia,erythrocyte series of bone marrow and iron metabolism after the treatment,so as to approach the effect of the Iron Sucrose Injection.Results After 5 weeks’ treatment of the 22 patients,the haematochrome(Hb)improved obviously(P<0.01).The accrementition and activity of the erythrocyte series of bone marrow improved obviously than pretherapy(P<0.01).And the serum iron,ferritin and the degree of saturation of transferrin were all raised obviously(P<0.01).Conclusion Intravenously guttae Iron Sucrose Injection can ensure the iron requirement of the EPO and reinforce the therapeutic effect.
【Key words】Iron Sucrose; Renal anaemia; Bone marrow manifestation; Iron metabolism
肾性贫血是维持性血液透析患者常见的并发症,随着基因重组人红细胞生成素(EPO)的广泛使用,明显改善了患者的肾性贫血 ......
您现在查看是摘要介绍页，详见PDF附件(2294KB，3页)。