卡介菌多糖核酸联合化学药物治疗肺结核合并糖尿病患者疗效观察
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【摘要】 目的 观察卡介菌多糖核酸在肺结核并发糖尿病中的治疗作用。方法 将60例肺结核合并糖尿病患者随机分为2组,实验组31例,对照组29例,两组患者均采用3HRZE/6HRZE/3HE治疗,其中试验组全疗程加用卡介菌多糖核酸,观察痰菌涂片、培养,X线检查、病变吸收及免疫指标的恢复情况。结果 ①病灶改变结果:试验组疗程结束时显效率93.5%;对照组显效率79.3%;②痰菌改变结果疗程结束时实验组100%,对照组86.25%;③空洞关闭情况:实验组86.2%,对照组69.2%;④免疫指标恢复结果:C3升高,CD4升高,CD8降低,LgG降低。结论 卡介菌多糖核酸联合化学药物治疗糖尿病菌阳患者,可以提高疗效,增强机体免疫力,减少结核病的复发,且未发现明显的毒副作用,适用于免疫功能低下的人群。
【关键词】卡介菌多糖核酸;肺结核合并糖尿病
【Abstract】 Objective To obsevative bacille calmette-guerin bacillus polysaccharide nucleic acid in pulmonary tuberculosis concurrent diabetes therapeutic action.Methods 60 example pulmonary tuberculosis merge diabetes patients were divided into2 groups,the experimental group 31 people and the control group 29 people Two grops of patients use the 3HRZE/6HRZE/3HE to treat.
The experimental group had entire treatment course to add with the bacille calmette-guerin bacillus polysaccharide nucleic acid,observation phlegm fungus smear,raise,X inspection,pathological change absorption and immunity target restoration situation.Results ①Infection changes the result:When experimental group treatment course conclusion obviously efficiency 93.5%; Control group obviously efficiency 79.3%;②phlegm fungus change result treatment course conclusion experimental group 100%,control group 86.25%;③empty closure situations:Experimental group 86.2%,control group 69.2%;④The immunity target restores the result:C3 elevates,CD4 elevates,CD8 reduces,LgG reduces.Conclusion Bacille calmette-guerin bacillus polysaccharide nucleic acid union chemistry pharmacological treatment the saccharorrhea germ positive patient,may enhance the curative effect,the enhancement organism immunity,reduces tuberculosis’s recrudescence,and the discovery obvious poisonous side effect,has not been suitable for the immunologic function low crowd.
【Key words】Bacille calmette-guerin bacillus polysaccharide nucleic acid;Pulmonary tuberculosis merge diabetes
随着人民生活水平的提高,糖尿病患者也日益增加,且糖尿病患者的糖,脂肪及蛋白质代谢紊乱,免疫功能下降,为结核菌感染提供了有利条件,成为诱发结核病的主要原因,糖尿病并发结核,发展迅速,症状难以控制,排菌率高,治愈率低。我院采用卡介菌多糖核酸联合化学药物对60例糖尿病菌阳患者治疗观察一年,取得了较好的疗效,报告如下。
1 资料与方法
1.1 一般资料对象 入选标准:①年龄:26~65岁,初治或治疗不超过2个月且痰菌阳性;②无严重的心,肝,肾,精神病及癫痫病史者;③近半年来未曾用过免疫抑制剂 ......
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