56例药物不良反应分析(1)
 |
| 第1页 |
参见附件(2309KB，3页)。
【摘要】 目的 分析我院药物不良反应(ADR)的发生特点及影响因素,促进临床合理用药。方法 采取回顾性方法,对我院2008~2009年上报的56份ADR报告,按患者年龄、性别、给药途径、引起ADR的药物种类、涉及脏器或系统以及临床表现等进行统计、分析。结果 静脉滴注较其他给药途径更易发生ADR(51例,占91.07%);心血管系统用药引发ADR的比例最高(24例,占42.86%),其次为抗感染药物与能量、输液类药;中药注射液是引发ADR的主要心血管系统用药(15例,占26.79%)。ADR的临床表现以皮疹、瘙痒等皮肤及其附件损害为主,其次为消化系统和免疫系统损害。结论 应加强药物使用的规范管理和加强ADR监测意识,完善相关报告分析制度。
【关键词】药物不良反应;心血管系统用药;报告分析
ADRreports analysis of 56 cases
QIU Xue-bing.Department of Pharmacy,Huiyang District People’s Hospital of HuiZhou City,GuangDong 516211,China
【Abstract】 Objective To analyze the features and general patterns of adverse drug reactions(ADR)occurred in our hospital.Methods By a retrospective study,56 ADR cases reports collected in the hospital in 2008~2009 were analyzed statistically in respect of patients,age and sex,route of administration,category of the drugs,organs and systems involved,and clinical manifestation of the ADR.Results The ADR were more likely caused via intravenous dip(51 cases,91.07%);ADR was caused by cardiovascular drugs(24 cases,42.86%),secondly by antiinfection drugs and then drugs for infusing energy.Chinese pharmaceutical injecting liquids were the major of cardiovascular drugs which result in ADR(15 cases,26.79%).The main presentation of the ADRwas damage of skin and its appendages such as erythra and pruritus etc.Besides,ADR causes the damage to digestive system and immanity system.Conclusion Great attention should be paid to standardizing the administration of using drugs,strengthening the consciousness of monitoring ADR and perfecting the regulation of analyzing related reports.
【Key words】
Adverse drug reaction;Cardiovascular drugs;Reports and analysis
开展药物不良反应(ADR)监测工作,一方面可以保障用药安全,避免ADR的发生;另一方面又可以促进合理用药,提高临床用药水平。本文对我院2008~2009年发生的56例ADR进行归类统计和分析,旨在发现和研究其发生的特点和规律,为临床合理用药提供更安全、更科学的依据。
1 资料与方法
1.1 一般资料 资料来源于我院门、急诊和住院部2008~2009年上报的56份ADR报告。
1.2 统计方法 依照ADR报告表,分别对发生ADR人群的性别、年龄、给药途径、药物种类、所涉及的器官或系统及临床表现等方面进行频数分析。
2 结果
2.1 ADR患者的年龄与性别分布 56例ADR中,男25例(占44.64%),女31例(占55.36%),男女之比为1:1.2,女性多于男性。患者年龄为6~87岁。发生ADR患者的年龄与性别分布见表1。
表1
发生ADR患者的年龄与性别分布
年龄(岁)病例数(例) ......
您现在查看是摘要介绍页，详见PDF附件(2309KB，3页)。