急性一氧化碳中毒患者血浆同型半胱氨酸浓度与血清TNF-α水平的相关性临床研究(1)
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【摘要】 目的 探讨急性一氧化碳(CO)中毒患者血浆同型半胱氨酸(Hcy)浓度与血清肿瘤坏死因子-α(TNF-α)水平与病情严重程度和对预后的关系。方法 将82例急性CO中毒患者分为三组:A组轻度组、B组中度组和C组重度组,应用ELISA法对82例急性CO中毒患者的血浆Hcy浓度与血清TNF-α水平进行检测。结果 重度组与中度组Hcy与TNF-α水平均明显高于轻度中毒组(P<0.01),且重度组明显高于中度组(P<0.05); 迟发性脑病患者均发生在重度组,其Hcy与TNF-α水平与其他组的比较差异有显著性(P<0.05)。结论 检测急性CO中毒患者的血浆Hcy浓度与血清TNF-α水平,有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生。
【关键词】一氧化碳中毒;同型半胱氨酸;肿瘤坏死因子-α;脑损伤;迟发性脑病
Relationship of Plasma Homocysteine Concentration with Serum Levels of TNF-αin Patients with acute carbonmonoxide poisoning
LIU Jian, LIU Si-guan, CHENG Wen-wei.Department of Emergency,Zaozhuang Municipal Hospital,Shandong 277100,China
【Abstract】 Objective To observe plasm homocysteine(Hcy)concentration and the serum levels of tumor necrosis factor-α(TNF-α)in patients and explore their relationship with the severe degree of acute carbonmonoxide poisoning and the prognostic value of the plasma homocysteine concentration and the serum levels of tumor necrosis factor-α.Methods 82 patients with acute carbon monoxide poisoning were divided into three groups:group A(gentleness poisoning group),group B(moderate poisoning group)and group C(severe poisoning group).The levels of Hcy and TNF-α of 82 patients were detected respectively with Enzyme-linked immunosobent assay ELISA.Results The level of Hcy and TNF-α in group B and group C were significantly higher than that in the control group A(P<0.05),Hcy and TNF-α level in group C was obviously higher than in group B also(P<0.05).There was statistically significant difference in the levels of Hcy and TNF-α between the patients with delayed encephalopathy which all occurred in group C and those in other groups(P<0.05).Conclusion Determination of Hcy and TNF-α level can contribute to assessing the severe degree of acute carbonmonoxide poisoning and it can also predict the occurrence of delayed encephalopathy.
【Key words】
Carbon monoxide poisoning; Homocysteine; Tumor necrosis factor-α; Braindamage; Encephalopathy
急性一氧化碳中毒(ACOP)是较为常见的生活性中毒和职业性中毒,致残、致死率高 ......
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