妫f牠銆�
閺堢喎鍨�: 瀵邦喕淇婇弬鍥╃彿 閸︺劎鍤庢稊锔剧潉 鐠у嫭鏋℃稉瀣祰 閸嬨儱鎮嶉弶鍌氱箶 閹躲儱鍨旈柅澶岀椽 閸╄櫣顢呴崠璇差劅 娑撴潙绨ラ崠璇差劅 閼筋垰顒� 鐎涳附濮� 娑擃厼娴楅崠璇差劅 閸楊偆鏁撻幀鏄忣啈
娣囨繂浠�: 閺備即妞� 鐠囧嫯顔� 鐟欏棛鍋� 鐢瓕鐦� 閻ゅ墽姊� 閻ュ洨濮� 閸忚崵鏁� 閻€劏宓� 閹躲倗鎮� 閹儲鏅� 閸嬨儴闊� 缂囧骸顔� 娑撱倖鈧拷 閼叉彃鍔� 閻拷 婵傦拷 閼帮拷 鐏忥拷 閸ユ稑顒� 鐠囪崵澧� 閺囨潙顦�
娑擃厼灏�: 鐢瓕鐦� 閺佹瑦娼� 閹繆鈧拷 娑擃叀宓� 閸栬崵鎮� 娑撴潙绨� 闁藉牓顎� 濮樻垶妫� 閺傚洤瀵� 閽佹ぞ缍� 妤犲本鏌� 閸ユ崘姘� 妞嬬喓鏋� 閼筋垳澧� 閼筋垯绗� 閼筋垰绔� 閺傛媽宓� 閹兼粎鍌� 閼昏鲸鏋�
当前位置: 首页 > 医学版 > 期刊论文 > 临床医学 > 中华急诊医学杂志 > 2010年 > 第11期 > 第11期 > 正文
编号:11974961
硫辛酸联合恩再适治疗化疗药物致周围神经病变的疗效分析(1)
http://www.100md.com 2010年11月1日 余彩玲


第1页

    参见附件(1973KB,3页)。

     【摘要】 目的 探讨a-硫辛酸联合中痘疫苗致炎兔皮提取物(恩再适)治疗化疗药物致周围神经病变的临床疗效。方法 2008年1月至2010年1月诊治的246例化疗药物致周围神经病变患者,随机分为治疗组126例;对照组120例;治疗组采用a-硫辛酸联合恩再适治疗,对照组采用甲钴胺注射液和维生素B12治疗;观察两组临床疗效。结果 治疗组总有效120例,总有效率95.23%,对照组总有效率99例,总有效率82.5%;两组总有效率比较,P<0.05有显著差异性。结论 a-硫辛酸联合恩再适治疗化疗药物致周围神经病变能够明显的增加感觉神经、运动神经传导速度,改善临床症状。a-硫辛酸联合恩再适治疗化疗药物致周围神经病变临床疗效确切,临床效果具有协同作用。在治疗期间无严重的不良反应,具有高度的安全性。

    【关键词】 a-硫辛酸;恩再适;化疗药物致周围神经病变;疗效分析

    Alpha lipoic acid combined analgecine on treatrment of chemotherapy in duced peripheral neuropathy

    

    YU Cai-ling.Internal secretion branch.The First people’s hospital of Shangqiu,Henan,Shangqiu 467100,China

    【Abstract】 Objective To study a-lipoic acid and then appropriate treatment of co-ex chemotherapy induced peripheral neuropathy clinical efficacy. Methods From January 2008 to 2010 in January 246 patients treated in chemotherapy induced peripheral neuropathy were randomly divided into treatment group 126 cases; the control group of 120 cases; treatment group was a-lipoic acid treatment combined grace and then apply the control group were Methylcobalamin Vitamin B12 Injection and treatment; clinical efficacy. Results The total effective of 120 cases, total effective rate 95.23%, the efficiency of the control group was 99 cases, 82.5%; group total effective rate was P<0.05 significant difference. Conclusion A-lipoic acid and then appropriate treatment of co-ex peripheral neuropathy caused by chemotherapy can significantly increase the sensory nerve, motor nerve conduction velocity, improve clinical symptoms. a-lipoic acid and then appropriate treatment of co-ex chemotherapy induced peripheral neuropathy is effective, the clinical effect is synergistic effect. During treatment,there was no serious adverse reactions, but with high security. 

    【Key words】 Alpha-lipoic acid;Analgecine;Chemotherapy induced peripheral neuropathy; Effect Analysis

    

    DOI:10.3760/cma.j.issn 1673-8799.2010.11.15

    作者单位:467100河南省商丘市第一人民医院

    随着生存年龄的增加,肿瘤患者逐渐增加,化疗是目前治疗恶性肿瘤的主要方法之一,在抗肿瘤化疗药物的不良反应中,由化疗药物所致的周围神经病变(chemotherapy-induced peripheral neuropa·thy,CIPN)是常见的副作用之一,临床表现为感觉运动多发性神经病,四肢对称性手套、袜套样深感觉、浅感觉障碍伴四肢远端肌力减退,跟腱反射减退或消失,重者出现肌萎缩[1] ......

您现在查看是摘要介绍页,详见PDF附件(1973KB,3页)
婵″倹鐏夐幃銊ユ躬娴h法鏁ら幍瀣簚缁涘绁︾憴鍫熸閺冪姵纭堕弻銉ф箙閹存牔绗呮潪钘夊弿閺傚浄绱濋崣顖濆厴閺勵垵顫﹂幖婊呭偍瀵洘鎼告径杈╂埂閳ユ粏娴嗛惍浣测偓婵撶礉鐠囬鍋i崙璇茬潌楠炴洘娓舵稉瀣煙閻ㄥ嫧鈧粎鏁搁懘鎴犲閳ユ繃鍨ㄩ垾婊冨斧缂冩垿銆夐垾婵婎問闂傤喓鈧拷


闂勬劒绨張宥呭閸c劌甯囬崝娑崇礉缂冩垹鐝柈銊ュ瀻娣団剝浼呴崣顏冪返閻栧崬绺炬导姘喅閹存牗婀佹稉鈧€规氨袧閸掑棛娈戝▔銊ュ斀娴兼艾鎲冲ù浣筋潔閵嗭拷
濮濓拷 pdf閸忋劍鏋� 闂団偓鐟曪拷 5 缁夘垰鍨庨敍鍫濆帳鐠愯鏁為崘宀€娅ヨぐ鏇炴倵濮e繐銇夐崣顖欎簰妫板棗褰�10娑擃亞袧閸掞拷閿涘鈧拷
    閺傚洨鐝烽悧鍫熸綀鐏炵偘绨崢鐔绘啿娴f粍娼堟禍鐚寸礉閼汇儲鍋嶇拋銈勮礋濮濄倖鏋冩稉宥呯杹鐞氼偅鏁硅ぐ鏇氱返婢堆冾啀閸忓秷鍨傞梼鍛邦嚢閿涘矁顕柇顔绘閹存牜鏁哥拠婵嬧偓姘辩叀閹存垳婊戦敍灞惧灉娴狀剚鏁归崚浼粹偓姘辩叀閸氬函绱濇导姘辩彌閸楀啿鐨㈤幃銊ф畱娴f粌鎼ф禒搴㈡拱缂冩垹鐝崚鐘绘珟閵嗭拷

   瀵邦喕淇婇弬鍥╃彿  閸忚櫕鏁為惂鐐  鐠囧嫯顔戦崙鐘插綖  閹兼粎鍌ㄩ弴鏉戭樋   閹恒劌鐡ㄧ紒娆愭箙閸欙拷   閸旂姴鍙嗛弨鎯版