内镜下注射治疗消化性溃疡出血的临床研究(1)
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【摘要】 目的 分析比较内镜下注射1%乙氧硬化醇和内镜下注射1：10 0000肾上腺素治疗消化性溃疡出血的疗效及安全性。方法 选自2009年7月至2010年7月因呕血和(或)黑便入院，经急诊内镜检查确诊为消化性溃疡出血患者120例，随机分成治疗组和对照组各60例。治疗组采用注射1%乙氧硬化醇止血治疗，对照组采用注射1：10 0000肾上腺素止血治疗，两组患者均由同一位医师操作完成。结果 治疗组止血成功率96.67%(58/60)，对照组止血成功率为92.98%(53/57),两组比较差异无统计学意义(P>0.05)；治疗组与对照组止血成功后3 h内再出血率分别为1.72%(1/58)，3.77%(2/53)，差异无统计学意义(P>0.05)，两组3~24 h内再出血率分别为3.45%(2/58)，16.98%(9/53)，两组比较差异有统计学意义(P<0.05)。两组患者随访2个月再出血率分别为1.72%(1/58)，1.89%(1/53)，差异无统计学意义(P>0.05)；随访6个月均未发现再出血。均未发现与治疗相关的并发症。两组患者的外科手术率、住院天数和死亡率差别没有统计学意义。 结论 内镜下注射硬化剂与肾上腺素均是治疗消化性溃疡出血的安全有效方法，并且内镜下注射乙氧硬化醇治疗。
【关键词】 内镜治疗; 消化性溃疡出血；硬化剂;肾上腺素
Clinical Study of Endoscopic Treatment in Patients with Peptic Ulcer Bleeding
HOU Yali,HUANG Liuye, LIU Yunxiang. Department of Gastroenterology, Yantai Yu huangding Hospital Afficialed to medical college of Qingdao University, Shandong 264000, China
【Abstract】 Objective To evaluate the effect of endoscopic sclerosing agent injection for treatment of Peptic Ulcer Bleeding. Methods From July 2009 to July 2010,120 patients with haematemesis and/or hematochezia diagnosed as peptic ulcer by immediate endoscopy were randomly divided into two groups:endoscopic aethoxysklerolinjection(n=60)and endoscopic 1:100000 epinephrine injection(n=60). All the patients were treated by the same endoscopist. Results The rate of hemostasis in therapy group was 96.67%(58/60), that in control group was 92.99%(P>0.05). The rebleeding rates of the earler 3 h in the therapy group and control group were 1.72%(1/58)and 3.77%(2/53),respectively,there was not significant differencein(P>0.05). The rebleeding rates between 3 h and 24 h in the therapy group and control group were 3.45%(2/58)and 16.98%(9/53),respectively,there wassignificant difference(P<0.05).2 months of follow up was made for the two groups, rebleeding rates in the therapy group and control group were 1.72%(1/58)and 1.89%(1/53),respectively,there was not significant difference(P>0.05). After 6 months of the observed,no one was found rebleeding. No complications related with treatment occurred in the two groups of patients ......
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